Vps9p Is a Guanine Nucleotide Exchange Factor Involved in Vesicle-mediated Vacuolar Protein Transport

Experiments in molecular genetics

1972 • 28,260 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae

1994 • 2,554 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual

2005 • 1,849 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

[21] β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast

1983 • 783 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Methods in yeast genetics, laboratory manual

1987 • 733 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function

1997 • 586 citations

Effects of the modification of transfer buffer composition and the renaturation of proteins in gels on the recognition of proteins on western blots by monoclonal antibodies

1986 • 539 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

1986 • 429 citations

GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

1994 • 411 citations

Isolation of yeast mutants defective in protein targeting to the vacuole.

1986 • 394 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

1993 • 340 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

1993 • 318 citations

Sec2p Mediates Nucleotide Exchange on Sec4p and Is Involved in Polarized Delivery of Post-Golgi Vesicles

1997 • 318 citations

Rab GTPases: master regulators of membrane trafficking

1994 • 315 citations

Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange

1994 • 313 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.

1996 • 284 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

1989 • 258 citations

Rab GDP Dissociation Inhibitor: Putting Rab GTPases in the Right Place

1995 • 240 citations

Endocytosis in yeast: Evidence for the involvement of a small GTP-binding protein (Ypt7p)

1992 • 235 citations

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.

1994 • 230 citations

Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange

1994 • 230 citations

A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor.

1997 • 219 citations

Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI

1997 • 218 citations

Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast.

1994 • 211 citations

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.

1994 • 190 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

1995 • 184 citations

Isolation and Characterization of a GDP/GTP Exchange Protein Specific for the Rab3 Subfamily Small G Proteins

1997 • 174 citations

A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family

1993 • 171 citations

A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.

1997 • 153 citations

Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles

1994 • 150 citations

Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.

1993 • 147 citations

A mitochondrial RNA maturase gene transferred to the yeast nucleus can control mitochondrial mRNA splicing

1986 • 135 citations

p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.

1996 • 127 citations

Yeast Vps45p is a Sec1p-like protein required for the consumption of vacuole-targeted, post-Golgi transport vesicles.

1994 • 127 citations

Specific interactions of Mss4 with members of the Rab GTPase subfamily.

1994 • 117 citations

DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function

1993 • 112 citations

Protein transport to the yeast vacuole

1995 • 102 citations

A Yeast Protein Related to a Mammalian Ras-Binding Protein, Vps9p, Is Required for Localization of Vacuolar Proteins

1996 • 82 citations

A Novel RING Finger Protein, Vps8p, Functionally Interacts with the Small GTPase, Vps21p, to Facilitate Soluble Vacuolar Protein Localization

1996 • 77 citations

Invasion of the Nucleotide Snatchers

1998 • 74 citations

Kinetics and thermodynamics of the interaction of elongation factor Tu with elongation factor Ts, guanine nucleotides, and aminoacyl-tRNA.

1985 • 53 citations

Genetic reconstitution of the high-affinity L-arabinose transport system

1989 • 46 citations

Interactions of Nucleotide Release Factor Dss4p with Sec4p in the Post-Golgi Secretory Pathway of Yeast

1997 • 44 citations

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.

1996 • 31 citations