Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

1987 • 491 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

1985 • 365 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1

1991 • 280 citations

The Son of sevenless Gene Product: a Putative Activator of Ras

1992 • 263 citations

CDC25 : a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae

1987 • 235 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

1991 • 196 citations

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.

1989 • 162 citations

Enhancement of the GDP-GTP Exchange of RAS Proteins by the Carboxyl-Terminal Domain of SCD25

1990 • 152 citations

Homologous activators of ras in fission and budding yeast

1990 • 142 citations

Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant

1991 • 112 citations

Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.

1987 • 101 citations

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

1992 • 91 citations

SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae.

1991 • 76 citations

Comparison of thermosensitive alleles of the CDC25 gene involved in the cAMP metabolism of Saccharomyces cerevisiae.

1990 • 70 citations

The Saccharomyces cerevisiae CDC25 gene product binds specifically to catalytically inactive ras proteins in vivo.

1992 • 65 citations

Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: Isolation of the MAK16 gene and analysis of an adjacent gene essential for growth at low temperatures

1987 • 62 citations

The C-terminal part of a gene partially homologous to CDC25 gene suppresses the cdc25-5 mutation in Saccharomyces cerevisiae

1989 • 57 citations

Cyclic GMP Cascade of Vision

1986 • 54 citations

Different kinetic properties of the two mutants, RAS2Ile152 and RAS2Val19, that suppress the CDC25 requirement in RAS/adenylate cyclase pathway in Saccharomyces cerevisiae.

1990 • 41 citations

Anti-Cdc25 Antibodies Inhibit Guanyl Nucleotide-Dependent Adenylyl Cyclase of Saccharomyces cerevisiae and Cross-React with a 150-Kilodalton Mammalian Protein

1992 • 25 citations

Computational sequence analysis revisited: new databases, software tools, and the research opportunities they engender.

1992 • 20 citations