The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Satisfying Hydrogen Bonding Potential in Proteins

1994 • 2,076 citations

Hydrogen bonding in globular proteins

1984 • 1,760 citations

Helix geometry in proteins

1988 • 1,042 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Electron-crystallographic Refinement of the Structure of Bacteriorhodopsin

1996 • 961 citations

OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences.

1993 • 917 citations

A Model Recognition Approach to the Prediction of All-Helical Membrane Protein Structure and Topology

1994 • 790 citations

Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA

1991 • 787 citations

Projection structure of rhodopsin

1993 • 758 citations

Transmembrane helices predicted at 95% accuracy

1995 • 669 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Optimization, Constraint, and History in the Evolution of Eyes

1990 • 627 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Prediction of Transmembrane Segments in Proteins Utilising Multiple Sequence Alignments

1994 • 466 citations

Molecular determinants of human red/green color discrimination

1994 • 462 citations

The evolution of α/β barrel enzymes

1990 • 378 citations

Structure and function of receptors coupled to G proteins

1994 • 377 citations

Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

1996 • 377 citations

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1994 • 373 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Structure and Function in Rhodopsin. 7. Point Mutations Associated with Autosomal Dominant Retinitis Pigmentosa

1994 • 309 citations

Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy

1995 • 278 citations

Correlation of co-ordinated amino acid substitutions with function in viruses related to tobacco mosaic virus

1987 • 275 citations

Resonance Raman spectroscopy of rhodopsin in retinal disk membranes

1974 • 274 citations

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.

1990 • 266 citations

A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor.

1994 • 260 citations

Structural Features and Light-Dependent Changes in the Cytoplasmic Interhelical E−F Loop Region of Rhodopsin: A Site-Directed Spin-Labeling Study

1996 • 259 citations

Retinal has a highly dipolar vertically excited singlet state: implications for vision.

1976 • 259 citations

The avian beta-adrenergic receptor: primary structure and membrane topology.

1986 • 252 citations

Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.

1995 • 242 citations

Structural classification of proteins: new superfamilies

1996 • 240 citations

Visual-pigment spectra: implications of the protonation of the retinal Schiff base

1976 • 236 citations

Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.

1993 • 235 citations

Determinants of visual pigment absorbance: role of charged amino acids in the putative transmembrane segments

1990 • 228 citations

A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.

1994 • 226 citations

Specific Tryptophan UV-Absorbance Changes Are Probes of the Transition of Rhodopsin to Its Active State

1996 • 226 citations

In Situ Microspectrophotometric Studies on the Pigments of Single Retinal Rods

1962 • 222 citations

Projection structure of frog rhodopsin in two crystal forms.

1995 • 220 citations

Constitutive activation of opsin: Influence of charge at position 134 and size at position 296

1993 • 218 citations

Related Contribution of Specific Helix 2 and 7 Residues to Conformational Activation of the Serotonin 5-HT2A Receptor

1995 • 217 citations

Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling

1996 • 213 citations

Site-directed Mutagenesis Identifies Residues Involved in Ligand Recognition in the Human A2a Adenosine Receptor

1995 • 202 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

Assignment of fingerprint vibrations in the resonance Raman spectra of rhodopsin, isorhodopsin, and bathorhodopsin: implications for chromophore structure and environment

1987 • 195 citations

Mapping of the amino acids in membrane-embedded helices that interact with the retinal chromophore in bovine rhodopsin

1991 • 193 citations

Determination of α-Helix Propensity within the Context of a Folded Protein

1994 • 181 citations

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor

1995 • 167 citations

Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning.

1992 • 160 citations

Mapping Light-Dependent Structural Changes in the Cytoplasmic Loop Connecting Helixes C and D in Rhodopsin: A Site-Directed Spin Labeling Study

1995 • 160 citations

Molecular flow resonance Raman effect from retinal and rhodopsin

1976 • 159 citations

Modeling α‐helical transmembrane domains: The calculation and use of substitution tables for lipid‐facing residues

1993 • 151 citations

A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

1993 • 146 citations

Photoactivated Conformational Changes in Rhodopsin: A Time-Resolved Spin Label Study

1993 • 140 citations

The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa.

1991 • 138 citations

Removal of the 9-methyl group of retinal inhibits signal transduction in the visual process. A fourier transform infrared and biochemical investigation

1989 • 131 citations

Identification of Glutamic Acid 113 as the Schiff Base Proton Acceptor in the Metarhodopsin II Photointermediate of Rhodopsin

1994 • 125 citations

Principles of Helix-Helix Packing in Proteins: The Helical Lattice Superposition Model

1996 • 124 citations

Rhodopsin's protein and carbohydrate structure: Selected aspects

1984 • 124 citations

Formation of the meta II photointermediate is accompanied by conformational changes in the cytoplasmic surface of rhodopsin

1993 • 120 citations

Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling.

1994 • 120 citations

Activating Mutations of Rhodopsin and Other G Protein-Coupled Receptors

1996 • 113 citations

Orientation of retinal in bovine rhodopsin determined by cross-linking using a photoactivatable analog of 11-cis-retinal.

1990 • 112 citations

A method for α‐helical integral membrane protein fold prediction

1994 • 112 citations

The ligand-binding domain of rhodopsin and other G protein-linked receptors

1992 • 107 citations

Localization of the retinal protonated Schiff base counterion in rhodopsin

1993 • 106 citations

A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins

1995 • 103 citations

Fourier-transform infrared difference spectroscopy of rhodopsin and its photoproducts at low temperature

1985 • 103 citations

The evolution and structure of aminergic G protein-coupled receptors.

1994 • 100 citations

[16] Stabilization of functional proteins by introduction of multiple disulfide bonds

1991 • 98 citations

Low-temperature solid-state carbon-13 NMR studies of the retinal chromophore in rhodopsin

1987 • 98 citations

Transverse location of the retinal chromophore of rhodopsin in rod outer segment disc membranes

1982 • 96 citations

Automated method for modeling seven-helix transmembrane receptors from experimental data

1995 • 95 citations

Evidence for a bound water molecule next to the retinal Schiff base in bacteriorhodopsin and rhodopsin: a resonance Raman study of the Schiff base hydrogen/deuterium exchange

1994 • 93 citations

NMR Constraints on the Location of the Retinal Chromophore in Rhodopsin and Bathorhodopsin

1995 • 91 citations

Identification of residues important for ligand binding to the human 5-hydroxytryptamine1A serotonin receptor.

1993 • 90 citations

pKa of the protonated Schiff base of bovine rhodopsin. A study with artificial pigments

1993 • 87 citations

Functional Interaction of Transmembrane Helices 3 and 6 in Rhodopsin

1996 • 85 citations

Construction of a High Affinity Zinc Switch in the k-Opioid Receptor

1996 • 79 citations

Arrangement of Transmembrane Domains in Adrenergic Receptors

1996 • 75 citations

Fourier transform infrared difference spectroscopy of rhodopsin mutants: Light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation

1993 • 74 citations

The orientation of the chromophore of vertebrate rhodopsin in the “meta” intermediate states and the reversibility of the meta II-meta III transition

1979 • 73 citations

High‐resolution solid‐state ¹³C‐NMR study of carbons C‐5 and C‐12 of the chromophore of bovine rhodopsin

1987 • 73 citations

Identification of intramolecular interactions in adrenergic receptors.

1992 • 73 citations

Mutational Analysis of the Relative Orientation of Transmembrane Helices I and VII in G Protein-coupled Receptors

1995 • 71 citations

Insertional mutagenesis as a probe of rhodopsin's topography, stability, and activity.

1994 • 69 citations

Structure of the third cytoplasmic loop of bovine rhodopsin

1995 • 69 citations

Solid-state NMR studies on the mechanism of the opsin shift in the visual pigment rhodopsin

1990 • 69 citations

Fourier Transform Infrared Study of the Rod Outer Segment Disk and Plasma Membranes of Vertebrate Retina

1994 • 68 citations

Projection Structure of an Invertebrate Rhodopsin

1996 • 64 citations

Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.

1993 • 64 citations

Critical Role of a Conserved Intramembrane Tyrosine Residue in Angiotensin II Receptor Activation

1995 • 64 citations

Interactions of the .BETA.-ionone Ring with the Protein in the Visual Pigment Rhodopsin Control the Activation Mechanism. An FTIR and Fluorescence Study on Artificial Vertebrate Rhodopsins

1994 • 64 citations

ORIENTATION OF AROMATIC RESIDUES IN RHODOPSIN. ROTATION OF ONE TRYPTOPHAN UPON THE META I→META II TRANSITION AFTER ILLUMINATION

1979 • 63 citations

Structures of Bacterial Photosynthetic Reaction Centers

1991 • 61 citations

Rhodopsin activation: Effects of the metarhodopsin I-metarhodopsin II equilibrium of neutralization or introduction of charged amino acids within putative transmembrane segments

1993 • 60 citations

MAGIC ANGLE SPINNING NMR STUDIES ON THE METARHODOPSIN II INTERMEDIATE OF BOVINE RHODOPSIN: EVIDENCE FOR AN UNPROTONATED SCHIFF BASE

1992 • 58 citations

Resonance Raman microprobe spectroscopy of rhodopsin mutants: effect of substitutions in the third transmembrane helix

1992 • 57 citations

FTIR Spectroscopy Reveals Microscopic Structural Changes of the Protein around the Rhodopsin Chromophore upon Photoisomerization

1995 • 56 citations

Disulfide Mutants of Barnase I: Changes in Stability and Structure Assessed by Biophysical Methods and X-ray Crystallography

1995 • 54 citations

Predicting the helix packing of globular proteins by self‐correcting distance geometry

1995 • 52 citations

The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors.

1993 • 49 citations

Two hypotheses ‐ one answer

1994 • 49 citations

Lys583 in the Third Extracellular Loop of the Lutropin/Choriogonadotropin Receptor Is Critical for Signaling

1996 • 48 citations

Effect of solvent polarizability on the absorption spectrum of all-trans-retinylpyrrolidiniminium perchlorate

1969 • 46 citations

Changing the location of the Schiff base counterion in rhodopsin

1992 • 44 citations

What Makes Red Visual Pigments Red? A Resonance Raman Microprobe Study of Retinal Chromophore Structure in Iodopsin

1994 • 44 citations

Movement of the retinylidene Schiff base counterion in rhodopsin by one helix turn reverses the pH dependence of the metarhodopsin I to metarhodopsin II transition.

1993 • 43 citations

Water structural changes in lumirhodopsin, metarhodopsin I, and metarhodopsin II upon photolysis of bovine rhodopsin: Analysis by Fourier transform infrared spectroscopy

1993 • 37 citations

SOLVENT EFFECTS ON THE SPECTRA OF RETINAL SCHIFF BASES—I. MODELS FOR THE BATHOCHROMIC SHIFT OF THE CHROMOPHORE SPECTRUM IN VISUAL PIGMENTS*

1977 • 36 citations

Pattern recognition and self‐correcting distance geometry calculations applied to myohemerythrin

1994 • 36 citations

Formation of 7-cis- and 13-cis-retinal pigments by irradiating squid rhodopsin

1979 • 32 citations

Structure and Function in Rhodopsin: Mapping of the Amino Acids in the Cytoplasmic Loop Connecting Helixes C and D and Chemical Reactivity in the Dark State Following Single Cysteine Replacements

1995 • 30 citations

Identification of Amino Acid Residues in Transmembrane Helices VI and VII of the Lutropin/Choriogonadotropin Receptor Involved in Signaling

1996 • 29 citations

High-resolution structural studies of the retinal-Glu113 interaction in rhodopsin

1995 • 28 citations

Labelling of the cytoplasmic domains of ovine rhodopsin with hydrophilic chemical probes

1984 • 27 citations

Wavelength regulation in iodopsin, a cone pigment

1989 • 27 citations

Modification of ovine opsin with the photosensitive hydrophobic probe 1-azido-4-[125I]iodobenzene. Labelling of the chromophore-attachment domain

1986 • 26 citations

Intramolecular interactions in muscarinic acetylcholine receptors studied with chimeric m2/m5 receptors.

1994 • 25 citations

QUANTUM YIELD OF CHAPSO‐SOLUBILIZED RHODOPSIN and 3‐HYDROXY RETINAL CONTAINING BOVINE OPSIN*

1991 • 20 citations

Computer simulations of signal transduction mechanism in α_1B-adrenergic and m3-muscarinic receptors

1995 • 19 citations

Identification of the sites in opsin modified by photoactivated azido[125I]iodobenzene

1986 • 18 citations

Amino acid sequence surrounding the retinal‐binding site in retinochrome of the squid, Todarodes pacificus

1993 • 13 citations

[Study of the molecular organization of visual rhodopsin in photoreceptor membranes by limited proteolysis].

1983 • 4 citations