The ligand-binding domain of rhodopsin and other G protein-linked receptors

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Three-dimensional model of purple membrane obtained by electron microscopy

1975 • 2,259 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family

1989 • 955 citations

Bacteriorhodopsin and the purple membrane of halobacteria

1979 • 909 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

The Drosophila ninaE gene encodes an opsin

1985 • 545 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Molecular Cloning of the Thyrotropin Receptor

1989 • 529 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

Isolation and structure of a rhodopsin gene from D. melanogaster

1985 • 481 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Site of Attachment of Retinal in Rhodopsin

1967 • 352 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Aspartic acid-96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin.

1989 • 318 citations

Bacteriorhodopsin, a membrane protein that uses light to translocate protons.

1988 • 293 citations

Resonance Raman spectroscopy of rhodopsin in retinal disk membranes

1974 • 274 citations

The structure of rhodopsin and the rod outer segment disk membrane

1983 • 248 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor

1990 • 215 citations

A rhodopsin gene expressed in photoreceptor cell R7 of the Drosophila eye: homologies with other signal-transducing molecules

1987 • 193 citations

Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function.

1991 • 183 citations

Octopus rhodopsin Amino acid sequence deduced from cDNA

1988 • 157 citations

An Insertion in the Human Thyrotropin Receptor Critical for High Affinity Hormone Binding

1990 • 153 citations

Site of attachment of retinal in bacteriorhodopsin.

1981 • 146 citations

An opsin gene expressed in only one photoreceptor cell type of the Drosophila eye

1986 • 134 citations

Photochemical cycle of bacteriorhodopsin studied by resonance Raman spectroscopy

1979 • 123 citations

The catecholamine binding site of the beta-adrenergic receptor is formed by juxtaposed membrane-spanning domains.

1988 • 121 citations

Molecular cloning and primary structure of squid (Loligo forbesi) rhodopsin, a phospholipase C-directed G-protein-linked receptor

1991 • 115 citations

Transducin Activation by Rhodopsin Without a Covalent Bond to the 11- Cis -Retinal Chromophore

1991 • 114 citations

Orientation of retinal in bovine rhodopsin determined by cross-linking using a photoactivatable analog of 11-cis-retinal.

1990 • 112 citations

Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis.

1990 • 108 citations

An opsin gene that is expressed only in the R7 photoreceptor cell of Drosophila.

1987 • 107 citations

Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis

1991 • 100 citations

ACID-BASE PROPERTIES OF RHODOPSIN AND OPSIN

1956 • 95 citations

Isolation and characterization of lamprey rhodopsin cDNA

1991 • 77 citations

Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding

1991 • 66 citations

Leutropin/beta-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface

1991 • 57 citations

Resonance Raman spectroscopy of octopus rhodopsin and its photoproducts

1987 • 34 citations

Cloning and structure-function of the H2 histamine receptor

1991 • 32 citations

Resonance raman spectra of octopus acid and alkaline metarhodopsins

1980 • 30 citations

3-H-YDROXYRETINAL AS A CHROMOPHORE OF Drosophila melanogaster VISUAL PIGMENT ANALYZED BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY

1986 • 26 citations