Functional Interaction of Transmembrane Helices 3 and 6 in Rhodopsin

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Sequence Alignment of the G-Protein Coupled Receptor Superfamily

1992 • 847 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Projection structure of rhodopsin

1993 • 758 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Molecular determinants of human red/green color discrimination

1994 • 462 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

1996 • 389 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin.

1992 • 307 citations

Specific Tryptophan UV-Absorbance Changes Are Probes of the Transition of Rhodopsin to Its Active State

1996 • 226 citations

Projection structure of frog rhodopsin in two crystal forms.

1995 • 220 citations

Mapping of the amino acids in membrane-embedded helices that interact with the retinal chromophore in bovine rhodopsin

1991 • 193 citations

Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296

1992 • 169 citations

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

1995 • 162 citations

Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning.

1992 • 160 citations

Mapping Light-Dependent Structural Changes in the Cytoplasmic Loop Connecting Helixes C and D in Rhodopsin: A Site-Directed Spin Labeling Study

1995 • 160 citations

Mapping the Binding Site Pocket of the Serotonin 5-Hydroxytryptamine2A Receptor

1996 • 142 citations

The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa.

1991 • 138 citations

Two-photon spectroscopy of locked-11-cis-rhodopsin: evidence for a protonated Schiff base in a neutral protein binding site.

1985 • 125 citations

A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

1994 • 121 citations

Orientation of retinal in bovine rhodopsin determined by cross-linking using a photoactivatable analog of 11-cis-retinal.

1990 • 112 citations

Localization of the retinal protonated Schiff base counterion in rhodopsin

1993 • 106 citations

The evolution and structure of aminergic G protein-coupled receptors.

1994 • 100 citations

Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells.

1995 • 93 citations

NMR Constraints on the Location of the Retinal Chromophore in Rhodopsin and Bathorhodopsin

1995 • 91 citations

Characterization of Rhodopsin Mutants That Bind Transducin but Fail to Induce GTP Nucleotide Uptake

1995 • 81 citations

The Effects of Amino Acid Replacements of Glycine 121 on Transmembrane Helix 3 of Rhodopsin

1996 • 77 citations

The Location of the Chromophore in Rhodopsin: A Photoaffinity Study

1994 • 53 citations

Characterization of Rhodopsin-Transducin Interaction: A Mutant Rhodopsin Photoproduct with a Protonated Schiff Base Activates Transducin

1994 • 48 citations

Changing the location of the Schiff base counterion in rhodopsin

1992 • 44 citations

What Makes Red Visual Pigments Red? A Resonance Raman Microprobe Study of Retinal Chromophore Structure in Iodopsin

1994 • 44 citations

Sequence divergence analysis for the prediction of seven-helix membrane protein structures: II. A 3-D model of human rhodopsin

1994 • 25 citations