Structure and function of receptors coupled to G proteins

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Projection structure of rhodopsin

1993 • 758 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness

1993 • 323 citations

Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin.

1992 • 307 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Constitutive activation of opsin: Influence of charge at position 134 and size at position 296

1993 • 218 citations

A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists

1993 • 211 citations

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.

1992 • 190 citations

Amino–aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

1993 • 185 citations

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

1992 • 175 citations

Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor.

1993 • 165 citations

The role of conserved aspartate and serine residues in ligand binding and in function of the 5‐HT_1A receptor: A site‐directed mutation study

1992 • 164 citations

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

1993 • 162 citations

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.

1992 • 160 citations

Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning.

1992 • 160 citations

Palmitoylation of bovine opsin and its cysteine mutants in COS cells.

1993 • 155 citations

Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis.

1992 • 144 citations

Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation

1993 • 142 citations

Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis

1992 • 134 citations

Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.

1992 • 130 citations

Domains for G-protein coupling in angiotensin II receptor type I: Studies by site-directed mutagenesis

1992 • 129 citations

Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.

1993 • 128 citations

Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor. Role of conserved cysteines in receptor function.

1992 • 126 citations

The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides

1992 • 118 citations

Molecular basis for the species selectivity of the substance P antagonist CP-96,345.

1993 • 118 citations

A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors.

1993 • 113 citations

Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II

1992 • 111 citations

Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors.

1992 • 97 citations

Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand-binding specificity.

1993 • 69 citations

Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.

1993 • 68 citations

Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor.

1993 • 67 citations

Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.

1993 • 64 citations

The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors.

1993 • 49 citations

The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding

1993 • 46 citations

Thyrotropin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors.

1992 • 44 citations

Changing the location of the Schiff base counterion in rhodopsin

1992 • 44 citations