Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Cytokine signal transduction

1994 • 1,358 citations

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

1994 • 1,253 citations

Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro¹

1998 • 1,211 citations

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

1998 • 1,177 citations

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

1997 • 1,149 citations

TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

1997 • 1,054 citations

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

1990 • 1,028 citations

Modulation of Osteoclast Differentiation

1992 • 1,014 citations

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

1990 • 1,012 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

Isolation of a Novel Cytokine from Human Fibroblasts That Specifically Inhibits Osteoclastogenesis

1997 • 791 citations

Severe Osteoporosis in Mice Lacking Osteoclastogenesis Inhibitory Factor/Osteoprotegerin

1998 • 774 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts

1998 • 571 citations

Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

1993 • 565 citations

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

1997 • 531 citations

Advances in Bone Biology: The Osteoclast*

1996 • 522 citations

The Bone Marrow-Derived Stromal Cell Lines MC3T3-G2/PA6 and ST2 Support Osteoclast-Like Cell Differentiation in Cocultures with Mouse Spleen Cells

1989 • 501 citations

The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor

1998 • 458 citations

MACROPHAGE COLONY STIMULATING FACTOR RESTORESIN VIVOBONE RESORPTION IN THEOP/OPOSTEOPETROTIC MOUSE

1990 • 441 citations

A Combination of Osteoclast Differentiation Factor and Macrophage-Colony Stimulating Factor Is Sufficient for both Human and Mouse Osteoclast Formation in Vitro

1998 • 418 citations

Regulation of Osteoclast Function

1997 • 411 citations

Interleukin-11: a new cytokine critical for osteoclast development.

1994 • 408 citations

Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK)

1998 • 408 citations

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

1995 • 396 citations

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor.

1991 • 359 citations

The human osteoclast precursor circulates in the monocyte fraction.

1996 • 347 citations

Osteoclast Differentiation Factor (ODF) Induces Osteoclast-like Cell Formation in Human Peripheral Blood Mononuclear Cell Cultures

1998 • 346 citations

Interleukin 1 Induces Multinucleation and Bone-Resorbing Activity of Osteoclasts in the Absence of Osteoblasts/Stromal Cells

1999 • 329 citations

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells.

1991 • 284 citations

Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells

1997 • 281 citations

Osteoclast Differentiation Factor Mediates an Essential Signal for Bone Resorption Induced by 1α,25-Dihydroxyvitamin D3, Prostaglandin E2, or Parathyroid Hormone in the Microenvironment of Bone

1998 • 243 citations

Identification of Committed Mononuclear Precursors for Osteoclast-Like Cells Formed in Long Term Human Marrow Cultures*

1990 • 232 citations

Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor

1998 • 201 citations

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.

1996 • 200 citations

Activation of NF-κB Is Involved in the Survival of Osteoclasts Promoted by Interleukin-1

1998 • 187 citations

[20] Role of 1α,25-dihydroxyvitamin D3 in osteoclast differentiation and function

1997 • 186 citations

Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact.

1996 • 182 citations

Stimulation of Osteoclast Formation by 1,25-Dihydroxyvitamin D Requires Its Binding to Vitamin D Receptor (VDR) in Osteoblastic Cells: Studies Using VDR Knockout Mice

1999 • 181 citations

TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption

1998 • 179 citations

Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity

1994 • 172 citations

Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cells.

1995 • 167 citations

Deficiency of Osteoclasts in Osteopetrotic Mice Is Due to a Defect in the Local Microenvironment Provided by Osteoblastic Cells*

1991 • 159 citations

Preparation and characterization of a mouse osteoclast-like multinucleated cell population

1992 • 159 citations

Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse.

1993 • 148 citations

Current Concepts Review - Cellular Biology of Bone-Resorbing Cells*

1996 • 146 citations

Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact.

1996 • 145 citations

Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitro

1991 • 134 citations

Interleukins in the Control of Osteoclast Differentiation

1998 • 113 citations

Macrophage colony-stimulating factor induces substantial osteoclast generation and bone resorption in human bone marrow cultures

1996 • 112 citations

New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro

1993 • 93 citations

Characterization of MCSF-induced proliferation and subsequent osteoclast formation in murine marrow culture

1995 • 91 citations

Interleukin-1α Activates an NF-κB-like Factor in Osteoclast-like Cells

1996 • 88 citations

Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy

1998 • 87 citations

Isolation and Characterization of Highly Enriched, Prefusion Mouse Osteoclastic Cells

1995 • 85 citations

Characterization of Monomeric and Homodimeric Forms of Osteoclastogenesis Inhibitory Factor

1998 • 85 citations

Identification of Osteoclast Precursors in Multilineage Hemopoietic Colonies*

1991 • 81 citations

Establishment and Characterization of an Immortal Macrophage-like Cell Line Inducible to Differentiate to Osteoclasts

1998 • 68 citations

Hypocalcemic Effect of Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in the Thyroparathyroidectomized Rat

1998 • 63 citations

Conditionally Immortalized Murine Bone Marrow Stromal Cells Mediate Parathyroid Hormone-Dependent Osteoclastogenesisin Vitro¹

1998 • 60 citations

Inhibition of bone resorption by 17β-estradiol in human bone marrow cultures

1998 • 52 citations

Human Osteoclast-Like Cells Are Formed from Peripheral Blood Mononuclear Cells in a Coculture with SaOS-2 Cells Transfected with the Parathyroid Hormone (PTH)/PTH-Related Protein Receptor Gene

1999 • 50 citations

Hormonal Regulation of Osteoclast Function

1998 • 43 citations

Isolation and characterization of osteoclast precursors that differentiate into osteoclasts on calvarial cells within a short period of time

1998 • 26 citations

An Ultrastructural Study of Cell-Cell Contact between Mouse Spleen Cells and Calvaria-Derived Osteoblastic Cells in a Co-Culture System for Osteoclast Formation.

1997 • 21 citations

Osteoclast Generation

2008 • 5 citations