Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

1999 • 1,621 citations

Secreted antagonists of the Wnt signalling pathway

2003 • 1,543 citations

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

2003 • 1,491 citations

The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption

2000 • 1,169 citations

Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma

1996 • 1,091 citations

Zoledronic Acid Is Superior to Pamidronate in the Treatment of Hypercalcemia of Malignancy: A Pooled Analysis of Two Randomized, Controlled Clinical Trials

2001 • 825 citations

Wnt signaling in osteoblasts and bone diseases

2004 • 794 citations

A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

2004 • 745 citations

Multiple myeloma; a review of 26 cases.

1957 • 682 citations

Evidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma

1974 • 681 citations

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

2001 • 525 citations

The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women

2001 • 487 citations

Serum markers of type I collagen formation and degradation in metabolic bone disease: Correlation with bone histomorphometry

1993 • 450 citations

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

2001 • 419 citations

Soluble receptor activator of nuclear factor κB ligand–osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index

2003 • 406 citations

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

2000 • 397 citations

Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma

1992 • 394 citations

A Phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

2003 • 386 citations

Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2

2005 • 342 citations

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

2005 • 318 citations

Osteoprotegerin Production by Human Osteoblast Lineage Cells Is Stimulated by Vitamin D, Bone Morphogenetic Protein-2, and Cytokines

1998 • 312 citations

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

2003 • 312 citations

Bisphosphonates Pamidronate and Zoledronic Acid Stimulate Osteoprotegerin Production by Primary Human Osteoblasts

2002 • 310 citations

Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity

2002 • 309 citations

Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma

2002 • 289 citations

In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates

1998 • 265 citations

RANK ligand and osteoprotegerin in myeloma bone disease

2003 • 260 citations

Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma.

1991 • 256 citations

Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

2002 • 248 citations

Stromal Cell-Derived Factor-1 (SDF-1) Recruits Osteoclast Precursors by Inducing Chemotaxis, Matrix Metalloproteinase-9 (MMP-9) Activity, and Collagen Transmigration

2003 • 238 citations

The role of MIP-1α in Inflammation and hematopoiesis

1996 • 218 citations

Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo.

2003 • 216 citations

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

2001 • 214 citations

Macrophage inflammatory protein 1-alpha (MIP-1α) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells

2003 • 214 citations

Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

2003 • 214 citations

Elevated Serum Levels of Stromal-Derived Factor-1α Are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients

2005 • 200 citations

Receptor activator of nuclear factor-κB ligand and osteoprotegerin

2001 • 191 citations

Cancer and the Microenvironment

2004 • 188 citations

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

2001 • 188 citations

Quantitative histology of myeloma‐induced bone changes

1982 • 183 citations

Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease

2001 • 172 citations

Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma.

2003 • 156 citations

The Nitrogen-Containing Bisphosphonate, Zoledronic Acid, Influences RANKL Expression in Human Osteoblast-Like Cells by Activating TNF-α Converting Enzyme (TACE)

2004 • 147 citations

Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin

1995 • 142 citations

Serum osteoprotegerin levels in healthy controls and cancer patients.

2002 • 133 citations

Multiple myeloma biology: lessons from the 5TMM models

2003 • 124 citations

Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts.

1995 • 115 citations

Tartrate‐resistant acid phosphatase isoform 5b: A novel serum marker for monitoring bone disease in multiple myeloma

2003 • 100 citations

Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma

2000 • 98 citations

Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function

2005 • 95 citations

Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation

2004 • 85 citations

Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease

2003 • 74 citations

Inhibition of Immature Erythroid Progenitor Cell Proliferation by Macrophage Inflammatory Protein-1α by Interacting Mainly With a C-C Chemokine Receptor, CCR1

1997 • 69 citations

Bone resorption parameters [carboxy‐terminal telopeptide of type‐I collagen (ICTP), amino‐terminal collagen type‐I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma

2002 • 64 citations

Proteasome inhibitors induce growth inhibition and apoptosis in myeloma cell lines and in human bone marrow myeloma cells irrespective of chromosome 13 deletion

2003 • 50 citations

Increased bone remodeling due to ovariectomy dramatically increases tumoral growth in the 5T2 multiple myeloma mouse model

2003 • 45 citations

Bone marrow metastatic myeloma cells promote osteoclastogenesis through RANKL on endothelial cells.

2003 • 36 citations

Myeloma affects both the growth and function of human osteoblast-like cells

1992 • 35 citations

Serum levels of carboxy-terminal telopeptide of type-I collagen are elevated in patients with multiple myeloma showing skeletal manifestations in magnetic resonance imaging but lacking lytic bone lesions in conventional radiography.

2003 • 35 citations

Serum osteocalcin concentrations in patients with multiple myeloma — correlation with disease stage and survival

1992 • 32 citations