Identifying genes that interact with Drosophila presenilin and amyloid precursor protein

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

2007 • 4,449 citations

Rab proteins as membrane organizers

2001 • 3,320 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Angiotensin-converting enzyme 2 is an essential regulator of heart function

2002 • 1,745 citations

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

2005 • 1,734 citations

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

2002 • 965 citations

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

2003 • 933 citations

Reconstitution of γ-secretase activity

2003 • 868 citations

The role of presenilin cofactors in the γ-secretase complex

2003 • 856 citations

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

2002 • 795 citations

painless, a Drosophila Gene Essential for Nociception

2003 • 791 citations

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

2003 • 744 citations

Calcium and neurodegeneration

2007 • 721 citations

Metals in Alzheimer's and Parkinson's Diseases

2008 • 663 citations

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

2006 • 660 citations

N<scp>OTCH AND</scp>P<scp>RESENILIN</scp>: Regulated Intramembrane Proteolysis Links Development and Degeneration

2003 • 640 citations

branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

1996 • 631 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors

2000 • 475 citations

Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila : A potential model for Alzheimer's disease

2004 • 472 citations

The Alzheimer's disease Beta-secretase enzyme, BACE1

2007 • 466 citations

Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

2005 • 426 citations

apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins.

1992 • 370 citations

Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing

1997 • 369 citations

Modulation of the Ryanodine Receptor and Intracellular Calcium

2007 • 362 citations

Filling out the Hippo pathway

2007 • 361 citations

Cell and molecular biology of Notch

2007 • 357 citations

The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

2002 • 355 citations

A directed screen for genes involved in Drosophila blood cell activation

2004 • 348 citations

Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease

2005 • 342 citations

The roles of receptor and ligand endocytosis in regulating Notch signaling

2005 • 335 citations

Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons

2000 • 310 citations

The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

2007 • 277 citations

Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in TransgenicDrosophila

2004 • 274 citations

A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster

2004 • 273 citations

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1

2002 • 272 citations

Dysregulated IP₃Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca²⁺Signals and Altered Membrane Excitability

2004 • 268 citations

Role of Drosophila α-Adaptin in Presynaptic Vesicle Recycling

1997 • 263 citations

Genetic Modifiers of Tauopathy in Drosophila

2003 • 261 citations

Drosophila Matrix Metalloproteinases Are Required for Tissue Remodeling, but Not Embryonic Development

2003 • 247 citations

Presenilins, the Endoplasmic Reticulum, and Neuronal Apoptosis in Alzheimer's Disease

1998 • 247 citations

The angiotensin converting enzyme (ACE)

2003 • 232 citations

PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1

2003 • 228 citations

Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production

2003 • 221 citations

FlyBase: anatomical data, images and queries

2005 • 217 citations

A common enzyme connects Notch signaling and Alzheimer's disease

2000 • 214 citations

Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila

1995 • 206 citations

The Tumor Suppressors Merlin and Expanded Function Cooperatively to Modulate Receptor Endocytosis and Signaling

2006 • 203 citations

Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-β Peptides Aβ40 and Aβ42

2006 • 198 citations

A Role for Drosophila IAP1-Mediated Caspase Inhibition in Rac-Dependent Cell Migration

2004 • 193 citations

DrosophilaDeltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling

2004 • 193 citations

Axonal Heparan Sulfate Proteoglycans Regulate the Distribution and Efficiency of the Repellent Slit during Midline Axon Guidance

2004 • 191 citations

A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila

2001 • 187 citations

The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”?

2007 • 187 citations

A Misexpression Screen Reveals Effects of bag-of-marbles and TGFβ Class Signaling on the Drosophila Male Germ-Line Stem Cell Lineage

2004 • 180 citations

FKBP12 Binding Modulates Ryanodine Receptor Channel Gating

2001 • 175 citations

Zygotic Lethal Mutations With Maternal Effect Phenotypes in Drosophila melanogaster. II. Loci on the Second and Third Chromosomes Identified by P-Element-Induced Mutations

1996 • 174 citations

Is inhibition of the renin–angiotensin system a new treatment option for Alzheimer's disease?

2007 • 170 citations

Nicastrin Is Required for γ-Secretase Cleavage of the Drosophila Notch Receptor

2002 • 168 citations

The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin

2005 • 166 citations

Presenilin diversifies its portfolio

2007 • 150 citations

FlyBase: integration and improvements to query tools

2007 • 146 citations

Senseless acts as a binary switch during sensory organ precursor selection

2003 • 141 citations

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

1990 • 141 citations

Different cofactor activities in γ-secretase assembly

2003 • 139 citations

A Sensitized Genetic Screen to Identify Novel Regulators and Components of the Drosophila Janus Kinase/Signal Transducer and Activator of Transcription Pathway

2003 • 137 citations

Bre1 Is Required for Notch Signaling and Histone Modification

2005 • 131 citations

Salvador-Warts-Hippo Signaling Promotes Drosophila Posterior Follicle Cell Maturation Downstream of Notch

2007 • 130 citations

Fray, a Drosophila Serine/Threonine Kinase Homologous to Mammalian PASK, Is Required for Axonal Ensheathment

2000 • 129 citations

Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling

2002 • 126 citations

Analysis and Inactivation of vha55, the Gene Encoding the Vacuolar ATPase B-subunit in Drosophila melanogaster Reveals a Larval Lethal Phenotype

1996 • 123 citations

Requirement of PEN-2 for Stabilization of the Presenilin N-/C-terminal Fragment Heterodimer within the γ-Secretase Complex

2004 • 120 citations

Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene.

1991 • 118 citations

Drosophila Rolling pebbles

2001 • 118 citations

Belle is a Drosophila DEAD-box protein required for viability and in the germ line

2004 • 113 citations

Regulation of RYR1 Activity by Ca²⁺ and Calmodulin

2000 • 111 citations

Characterization of differentially expressed genes in purified Drosophila follicle cells: Toward a general strategy for cell type-specific developmental analysis

1999 • 110 citations

Presenilin 2 Interacts with Sorcin, a Modulator of the Ryanodine Receptor

2000 • 110 citations

Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress

2001 • 110 citations

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease

2007 • 108 citations

A Misexpression Screen Identifies Genes That Can Modulate RAS1 Pathway Signaling in Drosophila melanogaster

2000 • 108 citations

Enhanced Ryanodine‐Mediated Calcium Release in Mutant PS1‐Expressing Alzheimer's Mouse Models

2007 • 107 citations

Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in Drosophila melanogaster

1999 • 104 citations

Epidermal Growth Factor Receptor and Transforming Growth Factor-β Signaling Contributes to Variation for Wing Shape in Drosophila melanogaster

2006 • 99 citations

Regulated Hyperaccumulation of Presenilin-1 and the “γ-Secretase” Complex

2003 • 99 citations

Presenilin structure, function and role in Alzheimer disease

2000 • 98 citations

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

2007 • 97 citations

Drosophila Immunity: Analysis of Larval Hemocytes by P-Element-Mediated Enhancer Trap

1997 • 96 citations

The Solved and Unsolved Mysteries of the Genetics of Early-Onset Alzheimer 's Disease

2002 • 95 citations

The ryanodine receptor is essential for larval development in Drosophila melanogaster

2000 • 94 citations

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

2000 • 93 citations

Identification of Novel Genes That Modify Phenotypes Induced by Alzheimer's β-Amyloid Overexpression in Drosophila

2008 • 92 citations

A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos

2003 • 90 citations

The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum.

1993 • 90 citations

Aph-1 Contributes to the Stabilization and Trafficking of the γ-Secretase Complex through Mechanisms Involving Intermolecular and Intramolecular Interactions

2005 • 87 citations

Increased Apoptotic Cell Death in Sporadic and Genetic Alzheimer's Disease

2003 • 84 citations

Drosophila presenilinIs Required for Neuronal Differentiation and Affects Notch Subcellular Localization and Signaling

1999 • 83 citations

Identification of Immune System and Response Genes, and Novel Mutations Causing Melanotic Tumor Formation in Drosophila melanogaster

1996 • 82 citations

Quantitative Trait Loci for Locomotor Behavior inDrosophila melanogaster

2006 • 79 citations

Endocytosis, Endosome Trafficking, and the Regulation ofDrosophilaDevelopment

2006 • 74 citations

Mutations Affecting the Development of the Peripheral Nervous System in Drosophila: A Molecular Screen for Novel Proteins

2000 • 73 citations

The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells

2004 • 72 citations

Drosophila Anterior-Posterior Polarity Requires Actin-Dependent PAR-1 Recruitment to the Oocyte Posterior

2006 • 72 citations

Copper homoeostasis in Drosophila melanogaster S2 cells

2004 • 70 citations

Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector

2007 • 67 citations

TheDrosophilatctex-1 Light Chain Is Dispensable for Essential Cytoplasmic Dynein Functions but Is Required during Spermatid Differentiation

2004 • 67 citations

Functional Conservation of the Active Sites of Human andDrosophilaAngiotensin I-Converting Enzyme

2000 • 67 citations

Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity

1998 • 66 citations

Independent roles of thedachshundandeyes absentgenes in BMP signaling, axon pathfinding and neuronal specification

2004 • 65 citations

Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum

1994 • 64 citations

Regulation of Drosophila TRPL Channels by Immunophilin FKBP59

2001 • 62 citations

Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis

2003 • 62 citations

Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian

2001 • 60 citations

Functional reconstitution of γ‐secretase through coordinated expression of presenilin, nicastrin, Aph‐1, and Pen‐2

2004 • 60 citations

Overlapping Functions of Argonaute Proteins in Patterning and Morphogenesis of Drosophila Embryos

2006 • 57 citations

TheDrosophilatrithorax group genetonalli(tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein

2002 • 57 citations

The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions

2004 • 57 citations

Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches

2002 • 56 citations

Krüppel-homolog is essential for the coordination of regulatory gene hierarchies in early Drosophila development

2004 • 53 citations

Angiotensin converting enzyme deletion allele in different kinds of dementia disorders

1999 • 52 citations

A Genetic Screen for Suppressors and Enhancers of the Drosophila PAN GU Cell Cycle Kinase Identifies Cyclin B as a Target

2001 • 49 citations

Functional Comparison of Human and Drosophila Hop Reveals Novel Role in Steroid Receptor Maturation

2005 • 49 citations

The hsp60B gene of Drosophila melanogaster is essential for the spermatid individualization process

2001 • 49 citations

Wing vein formation in Drosophila melanogaster: Hairless is involved in the cross-talk between Notch and EGF signaling pathways

2002 • 47 citations

Cyclin D-Cdk4 and Cyclin E-Cdk2 Regulate the JAK/STAT Signal Transduction Pathway in Drosophila

2003 • 47 citations

A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR

2006 • 45 citations

amontillado, the Drosophila Homolog of the Prohormone Processing Protease PC2, Is Required During Embryogenesis and Early Larval Development

2003 • 44 citations

Drosophila goosecoid participates in neural development but not in body axis formation.

1996 • 43 citations

Genetic Modifier Screens on Hairless Gain-of-Function Phenotypes Reveal Genes Involved in Cell Differentiation, Cell Growth and Apoptosis in Drosophila melanogaster

2005 • 43 citations

The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame

2003 • 42 citations

Drosophila PDZ-GEF, a Guanine Nucleotide Exchange Factor for Rap1 GTPase, Reveals a Novel Upstream Regulatory Mechanism in the Mitogen-Activated Protein Kinase Signaling Pathway

2002 • 39 citations

putzigIs Required for Cell Proliferation and Regulates Notch Activity inDrosophila

2007 • 36 citations

The Insertion Polymorphism in Angiotensin-Converting Enzyme Gene Associated With the APOE ε4 Allele Increases the Risk of Late-Onset Alzheimer Disease

2006 • 35 citations

The genetic architecture of odor-guided behavior in Drosophila melanogaster.

2001 • 34 citations

Evolution of the 12 kDa FK506‐binding protein gene

2007 • 33 citations

Identification and Characterization of Genes Involved in Embryonic Crystal Cell Formation During Drosophila Hematopoiesis

2004 • 33 citations

The Molecular Chaperone Hsp90 Is Required for mRNA Localization in Drosophila melanogaster Embryos

2007 • 33 citations

Identification of Genetic Loci That Interact With cut During Drosophila Wing-Margin Development

2005 • 27 citations

The Developmental Role of warthog, the Notch Modifier Encoding Drab6

1999 • 26 citations

Drosophila Calmodulin Mutants With Specific Defects in the Musculature or in the Nervous System

2003 • 25 citations

Identification of the Presenilins in Hematopoietic Cells with Localization of Presenilin 1 to Neutrophil and Platelet Granules

2002 • 23 citations

The Drosophila melanogaster gene for the NADH:ubiquinone oxidoreductase acyl carrier protein: developmental expression analysis and evidence for alternatively spliced forms

1999 • 22 citations

A Genetic Screen for Dominant Modifiers of a Small-Wing Phenotype in Drosophila melanogaster Identifies Proteins Involved in Splicing and Translation

2005 • 21 citations

An unusual genomic position effect on Drosophila white gene expression: pairing dependence, interactions with zeste, and molecular analysis of revertants.

1992 • 18 citations

Isolation and Characterization of Drosophila retinal degeneration B Suppressors

1999 • 17 citations

Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling

2004 • 16 citations

FKBP22 is part of chaperone/folding catalyst complexes in the endoplasmic reticulum of Neurospora crassa

2007 • 14 citations

A genetic screen for elements of the network that regulates neurogenesis in Drosophila

1998 • 12 citations

Precocious Expression of the Glide/Gcm Glial-Promoting Factor in Drosophila Induces Neurogenesis

2002 • 11 citations

Movement of calmodulin between cells in the ovary and embryo of drosophila

2004 • 8 citations