A Misexpression Screen Identifies Genes That Can Modulate RAS1 Pathway Signaling in Drosophila melanogaster

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

The MAPK signaling cascade

1995 • 3,300 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

AKAPs: from structure to function

1999 • 619 citations

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes.

1996 • 564 citations

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1998 • 510 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Systematic gain-of-function genetics in Drosophila

1998 • 467 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

The Role of the Genome Project in Determining Gene Function: Insights from Model Organisms

1996 • 450 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun

1999 • 373 citations

Chapter 33 Ectopic Expression in Drosophila

1994 • 360 citations

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

1996 • 357 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction

1995 • 312 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Regulators and Effectors of ras Proteins

1991 • 303 citations

A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP.

1994 • 291 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

Targeted selection of recombinant clones through gene dosage effects.

1983 • 262 citations

KSR modulates signal propagation within the MAPK cascade.

1996 • 252 citations

A Screen for Genes That Function Downstream of Ras1 During Drosophila Eye Development

1996 • 246 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

An Exploration of the Sequence of a 2.9-Mb Region of the Genome of Drosophila melanogaster: The Adh Region

1999 • 239 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

The Gene Search System: A Method for Efficient Detection and Rapid Molecular Identification of Genes in Drosophila melanogaster

1999 • 233 citations

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.

1994 • 216 citations

Insertion site preferences of the P transposable element in Drosophila melanogaster

2000 • 205 citations

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK

1998 • 196 citations

CNK, a RAF-Binding Multidomain Protein Required for RAS Signaling

1998 • 162 citations

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

1998 • 151 citations

A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region

1995 • 146 citations

Beadex encodes an LMO protein that regulates Apterous LIM–homeodomain activity in Drosophila wing development: a model for LMO oncogene function

1998 • 144 citations

Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways.

1997 • 142 citations

The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway

1998 • 142 citations

The Rap1 GTPase functions as a regulator of morphogenesis invivo

1999 • 141 citations

A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein

2000 • 127 citations

The Drosophila STE20-like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling

1999 • 104 citations

Mutations Modulating Raf Signaling in Drosophila Eye Development

1996 • 100 citations

A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

1998 • 100 citations

Dominant genetics using a yeast genomic library under the control of a strong inducible promoter.

1992 • 99 citations

MAPK Mediates RAS-induced Chromosome Instability

1999 • 95 citations

A Genetic Screen for Modifiers of a Kinase Suppressor of Ras-Dependent Rough Eye Phenotype in Drosophila

2000 • 88 citations

misshapen encodes a protein kinase involved in cell shape control in Drosophila

1997 • 51 citations

LK6, a short lived protein kinase in Drosophila that can associate with microtubules and centrosomes

1997 • 42 citations

A screen for mutations that prevent lethality caused by expression of activated sevenless and ras1 in theDrosophila embryo

1998 • 32 citations

Generation of a Novel A Kinase Anchor Protein and a Myristoylated Alanine-rich C Kinase Substrate-like Analog from a Single Gene

1999 • 27 citations