Genomic integrity and the repair of double-strand DNA breaks

DNA Repair and Mutagenesis

2006 • 4,725 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1999 • 1,322 citations

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1992 • 1,231 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

The DNA-dependent protein kinase

1999 • 896 citations

Catalysis of ATP-Dependent Homologous DNA Pairing and Strand Exchange by Yeast RAD51 Protein

1994 • 843 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

1996 • 670 citations

A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis

1998 • 668 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Similarity of the Yeast RAD51 Filament to the Bacterial RecA Filament

1993 • 654 citations

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

1998 • 636 citations

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

1998 • 625 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

1990 • 591 citations

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

1998 • 581 citations

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

1998 • 576 citations

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

2000 • 575 citations

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

1995 • 556 citations

Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

1997 • 551 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

1997 • 536 citations

RuvAB Acts at Arrested Replication Forks

1998 • 533 citations

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

1998 • 530 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

1998 • 503 citations

Frequent chromosomal translocations induced by DNA double-strand breaks

2000 • 498 citations

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

1996 • 492 citations

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

1993 • 486 citations

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

1995 • 484 citations

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

2000 • 484 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

ATM-dependent phosphorylation of nibrin in response to radiation exposure

2000 • 474 citations

Stimulation by Rad52 of yeast Rad51- mediated recombination

1998 • 459 citations

Model for Homologous Recombination During Transfer of DNA into Mouse L Cells: Role for DNA Ends in the Recombination Process

1984 • 457 citations

DNA strand annealing is promoted by the yeast Rad52 protein.

1996 • 455 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

1997 • 445 citations

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

1999 • 443 citations

Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

1997 • 438 citations

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations

1998 • 435 citations

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

1998 • 435 citations

A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair

1997 • 434 citations

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1998 • 431 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins

1998 • 426 citations

DNA recombination: the replication connection

1999 • 411 citations

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

1999 • 406 citations

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

1999 • 403 citations

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1999 • 402 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

2000 • 387 citations

Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae

1996 • 379 citations

Characterization of Double-Strand Break-Induced Recombination: Homology Requirements and Single-Stranded DNA Formation

1992 • 377 citations

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

1998 • 367 citations

Complex Formation and Functional Versatility of Mre11 of Budding Yeast in Recombination

1998 • 361 citations

DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes

1998 • 345 citations

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

1999 • 327 citations

Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

1998 • 323 citations

Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

1998 • 317 citations

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

2000 • 315 citations

Binding of double-strand breaks in DNA by human Rad52 protein

1999 • 314 citations

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1997 • 309 citations

DNA annealing by Rad52 Protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA

1998 • 305 citations

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

1997 • 305 citations

A Single-stranded DNA-binding Protein Is Needed for Efficient Presynaptic Complex Formation by the Saccharomyces cerevisiae Rad51 Protein

1997 • 301 citations

Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins.

1995 • 297 citations

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

1998 • 292 citations

DNA end-joining catalyzed by human cell-free extracts

1998 • 291 citations

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

1999 • 286 citations

Rad52 forms ring structures and co‐operates with RPA in single‐strand DNA annealing

1998 • 284 citations

Reduced X-Ray Resistance and Homologous Recombination Frequencies in a RAD54 Mutant of the Chicken DT40 Cell Line

1997 • 277 citations

Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae

1996 • 275 citations

DNA Length Dependence of the Single-Strand Annealing Pathway and the Role of Saccharomyces cerevisiae RAD59 in Double-Strand Break Repair

2000 • 270 citations

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

1997 • 267 citations

The Mre11-Rad50-Xrs2 Protein Complex Facilitates Homologous Recombination-Based Double-Strand Break Repair in Saccharomyces cerevisiae

1999 • 267 citations

Distinct roles of two separablein vitroactivities of yeast Mre11 in mitotic and meiotic recombination

1998 • 266 citations

The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair

2000 • 263 citations

RECOMBINATION BETWEEN REPEATED GENES IN MICROORGANISMS

1988 • 261 citations

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

1998 • 251 citations

Homologous and non-homologous recombination differentially affect DNA damage repair in mice

2000 • 245 citations

mre11S—a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis

1997 • 239 citations

A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae.

1996 • 234 citations

Ku70

1998 • 231 citations

Functional Differences and Interactions among the Putative RecA Homologs Rad51, Rad55, and Rad57

1995 • 228 citations

Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process.

1984 • 227 citations

Homologous Recombination, but Not DNA Repair, Is Reduced in Vertebrate Cells Deficient in RAD52

1998 • 226 citations

Human Rad50 Is Physically Associated with Human Mre11: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair

1996 • 219 citations

RAD1 and RAD10, but Not Other Excision Repair Genes, Are Required for Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

1995 • 217 citations

Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis

1999 • 213 citations

Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation

1999 • 213 citations

Two Pathways for Removal of Nonhomologous DNA Ends during Double-Strand Break Repair in Saccharomyces cerevisiae

1997 • 212 citations

okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis

1998 • 211 citations

XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination.

1992 • 207 citations

Double-Strand Break Repair Deficiency and Radiation Sensitivity in BRCA2 Mutant Cancer Cells

1998 • 202 citations

The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination

1996 • 189 citations

Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation.

1992 • 188 citations

Hypersensitivity ofKu80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development

1997 • 183 citations

Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins

1997 • 182 citations

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes

1998 • 177 citations

Structural Relationship of Bacterial RecA Proteins to Recombination Proteins from Bacteriophage T4 and Yeast

1993 • 172 citations

DNA-PK: at the cross-roads of biochemistry and genetics

1997 • 169 citations

Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53^−/− Background

1999 • 166 citations

The Mouse and Human Homologs of DMC1, the Yeast Meiosis-Specific Homologous Recombination Gene, Have a Common Unique form of Exon-Skipped Transcript in Meiosis

1996 • 165 citations

S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes.

1996 • 163 citations

Direct Association between the Yeast Rad51 and Rad54 Recombination Proteins

1996 • 158 citations

Chromosomal Rearrangements Occur in S. cerevisiae rfa1 Mutator Mutants Due to Mutagenic Lesions Processed by Double-Strand-Break Repair

1998 • 156 citations

Midgestation lethality in mice deficient for the RecA-related gene,Rad51d/Rad51l3

2000 • 154 citations

Cell cycle-dependent expression of the mouseRad51 gene in proliferating cells

1996 • 154 citations

Cloning the RAD51 homologue ofSchizosaccharomyces pombe

1993 • 153 citations

Human and mouse homologs of the Saccharomyces cerevisiaeRAD54 DNA repair gene: evidence for functional conservation

1996 • 152 citations

The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family

1998 • 149 citations

Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing

2000 • 148 citations

The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A

1997 • 142 citations

Identification, Characterization, and Genetic Mapping ofRad51d,a New Mouse and HumanRAD51/RecA-Related Gene

1998 • 137 citations

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

1999 • 135 citations

Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae

1996 • 131 citations

The fission yeast rad22 gene, having a function in matingtype switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae

1993 • 131 citations

Identification of a Novel HumanRAD51Homolog,RAD51B

1997 • 128 citations

Isolation and Characterization of the Human MRE11 Homologue

1995 • 127 citations

Position effects in ectopic and allelic mitotic recombination in Saccharomyces cerevisiae.

1989 • 123 citations

DNA replication triggered by double-stranded breaks in E. coli: Dependence on homologous recombination functions

1994 • 117 citations

The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight

1996 • 115 citations

Cloning and characterisation of theSchizosaccharomyces pombe rad32gene: a gene required for repair of double strand breaks and recombination

1995 • 108 citations

Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination

1994 • 107 citations

Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54 +, a gene involved in the repair of radiation damage and replication fidelity

1996 • 101 citations

Characterization of recombination intermediates from DNA injected into Xenopus laevis oocytes: evidence for a nonconservative mechanism of homologous recombination.

1991 • 99 citations

Effects of Mutations of RAD50, RAD51, RAD52, and Related Genes on Illegitimate Recombination in Saccharomyces cerevisiae

1996 • 97 citations

Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis

1997 • 93 citations

The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance

1999 • 86 citations

Homologous recombination in the fission yeast Schizosaccharomyces pombe: different requirements for the rhp51 + , rhp54 + and rad22 + genes

1997 • 84 citations

Repair of double-stranded DNA breaks by homologous DNA fragments during transfer of DNA into mouse L cells.

1990 • 82 citations

The frequency of meiotic recombination in yeast is independent of the number and position of homologous donor sequences: implications for chromosome pairing.

1991 • 80 citations

Polarity of DNA strand exchange promoted by recombination proteins of the RecA family

1998 • 72 citations

The Drosophila melanogaster RAD54 Homolog, DmRAD54, Is Involved in the Repair of Radiation Damage and Recombination

1997 • 70 citations

Some of the swi genes of Schizosaccharomyces pombe also have a function in the repair of radiation damage

1989 • 67 citations

The RAD52 Recombinational Repair Pathway is Essential in pol30 (PCNA) Mutants That Accumulate Small Single-Stranded DNA Fragments During DNA Synthesis

1998 • 67 citations

A New Recombinational DNA Repair Gene From Schizosaccharomyces pombe With Homology to Escherichia coli RecA

1999 • 65 citations

A Recombination Repair Gene of Schizosaccharomyces pombe, rhp57, Is a Functional Homolog of the Saccharomyces cerevisiae RAD57 Gene and Is Phylogenetically Related to the Human XRCC3 Gene

2000 • 65 citations

C1 inhibitor hinge region mutations produce dysfunction by different mechanisms

1992 • 64 citations

A Requirement for Recombinational Repair in Saccharomyces cerevisiae Is Caused by DNA Replication Defects of mec1 Mutants

1999 • 62 citations

Characterization of Strand Exchange Activity of Yeast Rad51 Protein

1997 • 61 citations

The Drosophila melanogaster DmRAD54 Gene Plays a Crucial Role in Double-Strand Break Repair after P-Element Excision and Acts Synergistically with Ku70 in the Repair of X-Ray Damage

1999 • 61 citations

Functions of the DNA dependent protein kinase.

1997 • 59 citations

Spontaneous and restriction enzyme-induced chromosomal recombination in mammalian cells.

1994 • 57 citations

Branch migration during Rad51-promoted strand exchange proceeds in either direction

1998 • 43 citations

Interchromosomal recombination is suppressed in mammalian somatic cells.

1995 • 40 citations

Budding yeast Rad50, Mre11, Xrs2, and Hdf1, but not Rad52, are involved in the formation of deletions on a dicentric plasmid

1997 • 35 citations

DNA repair: Rad52 – the means to an end

1999 • 33 citations

Double-Strand Break and Recombinational Repair in Saccharomyces cerevisiae

2003 • 31 citations

Test of the double-strand-break repair model of recombination in Xenopus laevis oocytes.

1992 • 30 citations

Genetics of genetics in Drosophila: P elements serving the study of homologous recombination, gene conversion and targeting

1995 • 28 citations

Cloning of the cDNA and genomic DNA that correspond to the recA-like gene of Drosophila melanogaster.

1994 • 28 citations

ArecA-like gene inDrosophila melanogaster that is expressed at high levels in female but not male meiotic tissues

1996 • 27 citations

Expression Profiles of a Human Gene Identified as a Structural Homologue of Meiosis-specific recA-like Genes

1995 • 26 citations

A recA -like gene in Drosophila melanogaster that is expressed at high levels in female but not male meiotic tissues

1996 • 11 citations

Deleted Work

1955 • 0 citations