Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

1998 • 785 citations

A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis

1998 • 668 citations

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

1998 • 581 citations

DNA Transposition by the RAG1 and RAG2 Proteins

1998 • 532 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1998 • 431 citations

Multicolour spectral karyotyping of mouse chromosomes

1996 • 313 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells

1998 • 286 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Novel approach to quantitative polymerase chain reaction using real-time detection: Application to the detection of gene amplification in breast cancer

1998 • 213 citations

Recent Advances in Understanding V(D)J Recombination

1997 • 196 citations

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

2000 • 194 citations

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1996 • 173 citations

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

1999 • 169 citations

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

1999 • 135 citations

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1996 • 106 citations

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.

1996 • 104 citations

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

1999 • 96 citations

Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage

1998 • 85 citations

No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma

1998 • 84 citations