Dematin interacts with the Ras‐guanine nucleotide exchange factor Ras‐GRF2 and modulates mitogen‐activated protein kinase pathways

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

1995 • 424 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling

2000 • 350 citations

The Nf2 Tumor Suppressor, Merlin, Functions in Rac-Dependent Signaling

2001 • 344 citations

Dbl family proteins

1997 • 260 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein βγ subunits

1996 • 178 citations

An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin

1992 • 160 citations

In Vivo, Villin Is Required for Ca2+-Dependent F-Actin Disruption in Intestinal Brush Borders

1999 • 149 citations

Cloning and Characterization of Ras-GRF2, a Novel Guanine Nucleotide Exchange Factor for Ras

1997 • 131 citations

Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity.

1988 • 129 citations

Molecular Characterization of abLIM, a Novel Actin-binding and Double Zinc Finger Protein

1997 • 121 citations

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

1999 • 108 citations

Partial purification and characterization of an actin-bundling protein, band 4.9, from human erythrocytes.

1985 • 107 citations

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

1992 • 91 citations

The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways

1998 • 91 citations

Expression Cloning of lsc, a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors

1996 • 91 citations

Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf

1999 • 88 citations

Abolition of actin-bundling by phosphorylation of human erythrocyte protein 4.9

1988 • 88 citations

Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli

1998 • 86 citations

The junctional complex of the membrane skeleton.

1993 • 86 citations

G protein βγ subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25 ^Mm

1999 • 83 citations

Isoform Cloning, Actin Binding, and Chromosomal Localization of Human Erythroid Dematin, a Member of the Villin Superfamily

1995 • 74 citations

Cloning of human erythroid dematin reveals another member of the villin family.

1993 • 72 citations

Purification of Erythrocyte Dematin (protein 4.9) Reveals an Endogenous Protein Kinase That Modulates Actin-bundling Activity

1989 • 51 citations

Loss of Heterozygosity on 8p in Prostate Cancer Implicates a Role for Dematin in Tumor Progression

1999 • 41 citations

Human Erythrocyte Dematin and Protein 4.2 (Pallidin) Are ATP Binding Proteins

1996 • 23 citations

Alternative splicing and structure of the human erythroid dematin gene

1998 • 14 citations

cDNA sequence, genomic structure, and expression of the mouse dematin gene ( Epb4.9 )

1999 • 5 citations