Molecular Biology of Burkitt’s Lymphoma

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

National cancer institute sponsored study of classifications of non-hodgkin's lymphomas. Summary and description of a working formulation for clinical usage

1982 • 3,027 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA

1964 • 2,643 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

1997 • 1,015 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation

1986 • 927 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

2000 • 897 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Direct activation of TERT transcription by c-MYC

1999 • 871 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

Myc activates telomerase

1998 • 650 citations

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

2000 • 575 citations

Oncogenic activity of the c-Myc protein requires dimerization with Max

1993 • 543 citations

Lymphoid Neoplasia Associated with the Acquired Immunodeficiency Syndrome (AIDS)

1988 • 518 citations

Translocation and Rearrangements of the c- myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas

1983 • 514 citations

Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen.

1996 • 481 citations

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma study group

1995 • 480 citations

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

2000 • 479 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

The Pathogenesis of Burkitt's Lymphoma

1990 • 477 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

2000 • 447 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc

1999 • 427 citations

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

1999 • 409 citations

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor

1999 • 388 citations

Function of the c-Myc Oncogenic Transcription Factor

1999 • 379 citations

Cytogenetic findings in 200 patients with multiple myeloma

1995 • 378 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

1995 • 372 citations

Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma.

1986 • 371 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Diverse karyotypic abnormalities of the c -myc locus associated with c -myc dysregulation and tumor progression in multiple myeloma

2000 • 344 citations

Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice.

1996 • 332 citations

Differential Expression of the Translocated and the Untranslocated c- myc Oncogene in Burkitt Lymphoma

1983 • 328 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points

1999 • 319 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 319 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1999 • 285 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

AIDS-related lymphoma. Histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization.

1991 • 283 citations

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

1998 • 280 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

2000 • 276 citations

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

1984 • 274 citations

Dap-Kinase Participates in TNF-α–And FAS-Induced Apoptosis and Its Function Requires the Death Domain

1999 • 272 citations

Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)

1999 • 270 citations

Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

1988 • 260 citations

Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: relevance to geography and Epstein-Barr virus association

1991 • 257 citations

Oncogenic Role of Epstein-Barr Virus-Encoded RNAs in Burkitt’s Lymphoma Cell Line Akata

1999 • 255 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 248 citations

Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.

1993 • 246 citations

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

1988 • 245 citations

An Essential E Box in the Promoter of the Gene Encoding the mRNA Cap-Binding Protein (Eukaryotic Initiation Factor 4E) Is a Target for Activation by c-myc

1996 • 232 citations

Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma

1987 • 228 citations

Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

1988 • 224 citations

Recombinant Epstein-Barr virus with small RNA (EBER) genes deleted transforms lymphocytes and replicates in vitro.

1991 • 220 citations

Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells

1996 • 219 citations

Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.

1996 • 210 citations

Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia

2000 • 204 citations

c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.

1988 • 195 citations

The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining

1986 • 184 citations

Small Noncleaved, Non-Burkitt's (Burkitt-Like) Lymphoma: Cytogenetics Predict Outcome and Reflect Clinical Presentation

1999 • 183 citations

Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency.

1993 • 182 citations

New Myc-interacting proteins: a second Myc network emerges

1999 • 178 citations

Epstein-Barr Virus (EBV) in Endemic Burkitt's Lymphoma: Molecular Analysis of Primary Tumor Tissue

1998 • 176 citations

Chromatin Remodeling and Leukemia: New Therapeutic Paradigms

1999 • 173 citations

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets

1998 • 173 citations

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

1997 • 171 citations

An E-Box-Mediated Increase in cad Transcription at the G₁/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

1995 • 169 citations

Myc versus USF: Discrimination at the cad Gene Is Determined by Core Promoter Elements

1997 • 165 citations

African Burkitt's lymphoma. History, biology, clinical features, and treatment.

1991 • 160 citations

Regulation of cell cycle duration by c-myc levels.

1989 • 155 citations

Transcriptional control of the endogenous MYC protooncogene by antisense RNA.

1987 • 153 citations

Opposite regulation of gene transcription and cell proliferation by c-Myc and Max.

1993 • 146 citations

Molecular and Clinical Features of Non-Burkitt’s, Diffuse Large-Cell Lymphoma of B-Cell Type Associated With the c-MYC/Immunoglobulin Heavy-Chain Fusion Gene

2000 • 144 citations

Chromatin Remodeling and Leukemia: New Therapeutic Paradigms

1999 • 139 citations

Molecular epidemiology of Burkitt's lymphoma from South America: differences in breakpoint location and Epstein-Barr virus association from tumors in other world regions

1992 • 138 citations

African Burkittʼs Lymphoma

1991 • 138 citations

Tra1p Is a Component of the Yeast Ada·Spt Transcriptional Regulatory Complexes

1998 • 137 citations

Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions

1998 • 130 citations

myc Boxes, Which Are Conserved in myc Family Proteins, Are Signals for Protein Degradation via the Proteasome

1998 • 130 citations

Burkitt-like lymphomas in AIDS patients: characterization within a series of 103 human immunodeficiency virus-associated non-Hodgkin's lymphomas. Burkitt's Lymphoma Study Group.

1998 • 129 citations

Epstein-Barr Virus Regulates c-MYC, Apoptosis, and Tumorigenicity in Burkitt Lymphoma

1999 • 128 citations

Myc-mediated transformation: the repression connection

1999 • 126 citations

DAP-kinase Participates in TNF-alpha and Fas-induced Apoptosis and Its Function Requires the Death Domain

1999 • 124 citations

Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11)

1990 • 113 citations

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection

1996 • 109 citations

Variable breakpoints in Burkitt lymphoma cells with chromosomal t(8; 14) translocation separate c-myc and the IgH locus up to several hundred kb

1992 • 103 citations

A Point Mutation in the c- myc Locus of a Burkitt Lymphoma Abolishes Binding of a Nuclear Protein

1988 • 102 citations

Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity

1997 • 99 citations

Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

1995 • 98 citations

Histogenetic correlations between subcategories of small noncleaved cell lymphomas

1992 • 95 citations

Burkitt's lymphoma in adults with and without human immunodeficiency virus infection

1998 • 94 citations

Lymphomas associated with HIV infection.

1997 • 87 citations

The roles of human viruses in the pathogenesis of lymphoma.

1998 • 84 citations

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

1995 • 79 citations

Jaw involvement in American Burkitt's lymphoma

1984 • 76 citations

Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network

1999 • 68 citations

A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma.

1994 • 67 citations

Identification of a novel protein encoded by the BamHI A region of the Epstein-Barr virus

1997 • 66 citations

Role of histone deacetylases in acute leukemia

1998 • 65 citations

ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.

1996 • 64 citations

A novel function for Myc: inhibition of C/EBP-dependent gene activation.

1996 • 61 citations

Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma

1999 • 60 citations

Central nervous system involvement in American Burkitt's lymphoma.

1983 • 60 citations

Chromosomal abnormalities in adult non‐endemic burkitt's lymphoma and leukemia: 22 new reports and a review of 148 cases from the literature

1991 • 59 citations

Insight into Burkitt's Lymphoma from Immunoglobulin Variable Region Gene Analysis

1998 • 54 citations

Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells.

1997 • 53 citations

The t(8;14) chromosome translocation of the Burkitt lymphoma cell line Daudi occurred during immunoglobulin gene rearrangement and involved the heavy chain diversity region.

1987 • 52 citations

Sin3 corepressor function in Myc-induced transcription and transformation.

1996 • 47 citations

C-Myc binds to 5′ flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation

1994 • 47 citations

Mnt: A Novel Max-interacting Protein and Myc Antagonist

1997 • 46 citations

Retroviral infection accelerates T lymphomagenesis in E mu-N-ras transgenic mice by activating c-myc or N-myc.

1992 • 43 citations

Cytogenetic and molecular analysis of 6q deletions in burkitt's lymphoma cell lines

1994 • 42 citations

Phosphorylation-dependent binding of a 138-kDa myc intron factor to a regulatory element in the first intron of the c-myc gene.

1990 • 41 citations

Subtracted, Unique-Sequence, In Situ Hybridization

1998 • 37 citations

Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma

1997 • 37 citations

Point mutations of the BCL‐6 gene in Burkitt's lymphoma

1997 • 33 citations

The immunology of AIDS‐associated lymphomas

1998 • 33 citations

B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Emu).

1999 • 31 citations

Surgical resection and limited chemotherapy for abdominal undifferentiated lymphomas.

1984 • 30 citations

Cellular Targets for Activation by c-Myc Include the DNA Metabolism Enzyme Thymidine Kinase

1997 • 29 citations

Malignant lymphomas with band 8q24 chromosome abnormality: a morphologic continuum extending from Burkitt's to immunoblastic lymphoma

1984 • 29 citations

Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry

1999 • 27 citations

Expression and Function of Recombination Activating Genes in Mature В Cells

1998 • 23 citations

Complete nucleotide sequence of ig v genes in three cases of burkitt lymphoma associated with AIDS

1996 • 20 citations

Mutations of the p53 Gene in B-cell Lymphoma

1993 • 16 citations

17p Anomalies in Lymphoid Malignancies: Diagnostic and Prognostic Implications

1995 • 16 citations

Variant (8;22) Translocation in Lymphoblastic Lymphoma

1996 • 14 citations

Dissection of c-myc domains involved in S phase induction of NIH3T3 fibroblasts.

1994 • 10 citations