Chromatin Remodeling and Leukemia: New Therapeutic Paradigms

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Spheroid Chromatin Units (ν Bodies)

1974 • 1,366 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Sodium butyrate inhibits histone deacetylation in cultured cells

1978 • 1,008 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

1996 • 830 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

1996 • 756 citations

Nuclear receptor coactivators

1997 • 720 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

DNA methylation and gene expression

1991 • 685 citations

RSC, an Essential, Abundant Chromatin-Remodeling Complex

1996 • 680 citations

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

1996 • 662 citations

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

1993 • 658 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

ACF, an ISWI-Containing and ATP-Utilizing Chromatin Assembly and Remodeling Factor

1997 • 624 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1995 • 587 citations

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

1997 • 585 citations

Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

1998 • 571 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

1998 • 568 citations

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1998 • 525 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

1993 • 510 citations

Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO

1998 • 500 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

1993 • 484 citations

Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.

1978 • 474 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion

1996 • 463 citations

Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences.

1978 • 459 citations

ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

1998 • 442 citations

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

1996 • 421 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

The histone acetylase PCAF is a nuclear receptor coactivator

1998 • 389 citations

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

1998 • 363 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)

1995 • 352 citations

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1997 • 343 citations

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia

1997 • 341 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1998 • 308 citations

Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia

1998 • 303 citations

Crystal structure of the BTB domain from PLZF

1998 • 301 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis

1998 • 295 citations

Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein

1998 • 286 citations

Human SWI/SNF Interconverts a Nucleosome between Its Base State and a Stable Remodeled State

1998 • 283 citations

Steroid receptor induction of gene transcription: A two-step model

1997 • 269 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 264 citations

A Novel Fusion Between MOZ and the Nuclear Receptor Coactivator TIF2 in Acute Myeloid Leukemia

1998 • 248 citations

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

1998 • 245 citations

SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.

1996 • 244 citations

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

1994 • 241 citations

The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene

1997 • 240 citations

Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression

1997 • 236 citations

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.

1993 • 233 citations

A Novel Fusion Between MOZ and the Nuclear Receptor Coactivator TIF2 in Acute Myeloid Leukemia

1998 • 227 citations

Chromatin remodeling and transcription

1997 • 227 citations

All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders

1997 • 219 citations

The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

1995 • 212 citations

Activated RSC–Nucleosome Complex and Persistently Altered Form of the Nucleosome

1998 • 198 citations

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

1990 • 196 citations

Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells.

1999 • 195 citations

Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11.

1996 • 193 citations

Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A

1988 • 192 citations

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

1990 • 190 citations

Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays

1997 • 184 citations

Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding

1998 • 180 citations

Binding of Trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis

1998 • 179 citations

Effects of trichostatins on differentiation of murine erythroleukemia cells.

1987 • 171 citations

Overcoming a nucleosomal barrier to transcription

1995 • 168 citations

Distinct steady–state nuclear receptor coregulator complexes exist in vivo

1998 • 165 citations

Effect of polar organic compounds on leukemic cells: Butyrate-induced partial remission of acute myelogenous leukemia in a child

1983 • 164 citations

A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line.

1992 • 160 citations

TFG3/TAF30/ANC1, a Component of the Yeast SWI/SNF Complex That Is Similar to the Leukemogenic Proteins ENL and AF-9

1996 • 158 citations

The Yeast SWI-SNF Complex Facilitates Binding of a Transcriptional Activator to Nucleosomal Sites In Vivo

1997 • 139 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

Long-term survival of patients with acute myeloid leukemia

1997 • 131 citations

Role of Nucleosome Remodeling Factor NURF in Transcriptional Activation of Chromatin

1997 • 129 citations

Leukemic Cellular Retinoic Acid Resistance and Missense Mutations in the PML-RAR Fusion Gene After Relapse of Acute Promyelocytic Leukemia From Treatment With All-trans Retinoic Acid and Intensive Chemotherapy

1998 • 128 citations

trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each

1993 • 119 citations

Long-term survival in acute myeloid leukemia: the Eastern Cooperative Oncology Group experience.

1997 • 117 citations

Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.

1991 • 114 citations

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

1995 • 113 citations

p300 and CBP as transcriptional regulators and targets of oncogenic events.

1996 • 110 citations

Histone Acetylation Is Required to Maintain the Unfolded Nucleosome Structure Associated with Transcribing DNA

1998 • 110 citations

Butyrate and phenylacetate as differentiating agents: Practical problems and opportunities

1995 • 107 citations

CpG methylation remodels chromatin structure in vitro

1997 • 101 citations

Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure.

1996 • 97 citations

Molecular Analysis of the SNF2/SWI2 Protein Family Member MOT1, an ATP-Driven Enzyme That Dissociates TATA-Binding Protein from DNA

1997 • 96 citations

p300/CREB Binding Protein-Related Protein p270 Is a Component of Mammalian SWI/SNF Complexes

1998 • 90 citations

ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease

1996 • 88 citations

Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia.

1996 • 86 citations

Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient.

1994 • 82 citations

Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila

1991 • 82 citations

SWI-SNF Complex Participation in Transcriptional Activation at a Step Subsequent to Activator Binding

1998 • 81 citations

TGGA repeats impair nucleosome formation

1998 • 81 citations

A Conformational Switch in Nuclear Hormone Receptors Is Involved in Coupling Hormone Binding to Corepressor Release

1997 • 81 citations

Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission

1994 • 72 citations

Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid

1997 • 72 citations

Long-term survival in acute myeloid leukemia

1997 • 70 citations

Complete exon structure of the ALL1 gene.

1996 • 68 citations

Overexpression, Purification, Characterization, and Crystallization of the BTB/POZ Domain from the PLZF Oncoprotein

1997 • 68 citations

A new variant translocation in acute promyelocytic leukaemia: molecular characterization and clinical correlation.

1996 • 66 citations

Phenylacetate and Phenylbutyrate as Novel, Nontoxic Differentiation Inducers

1997 • 58 citations

ALL1 gene alterations in acute leukemia: biological and clinical aspects.

1998 • 57 citations

Clusters of nucleosomes containing chromosomal protein HMG-17 in chromatin

1997 • 54 citations

Sin3 corepressor function in Myc-induced transcription and transformation.

1996 • 47 citations

Interaction of steroid hormone receptors with transcription factors involves chromatin remodelling

1996 • 45 citations

Structure and expression of the human trithorax-like gene 1 involved in acute leukemias.

1993 • 45 citations

Anaerobic degradation of trans-cinnamate and ω-phenylalkane carboxylic acids by the photosynthetic bacterium Rhodopseudomonas palustris: evidence for a β-oxidation mechanism

1992 • 38 citations

MLL fusion genes in the 11q23 acute leukemias

1996 • 28 citations

High Mobility Group Proteins 14 and 17 Can Prevent the Close Packing of Nucleosomes by Increasing the Strength of Protein Contacts in the Linker DNA

1996 • 25 citations

Transcriptional Regulation by the t(8;21 )Fusion Protein, AML-1/ETO

1996 • 22 citations

Nucleosome assembly on the human c-fos promoter interferes with transcription factor binding

1996 • 19 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 19 citations

Transformation properties of the ETO gene, fusion partner in t(8:21) leukemias.

1997 • 19 citations

Ligand-induced Conformational Changes in the Human Retinoic Acid Receptor γ Detected Using Monoclonal Antibodies

1996 • 13 citations

Evidence That Partial Unwrapping of DNA from Nucleosomes Facilitates the Binding of Heat Shock Factor following DNA Replication in Yeast

1998 • 11 citations

ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease

1996 • 11 citations

Leukemic Cellular Retinoic Acid Resistance and Missense Mutations in the PML-RAR Fusion Gene After Relapse of Acute Promyelocytic Leukemia From Treatment With All-trans Retinoic Acid and Intensive Chemotherapy

1998 • 3 citations