VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

A sarcoma involving the jaws in african children

1958 • 1,307 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

The Pathogenesis of Burkitt's Lymphoma

1990 • 477 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma

1983 • 286 citations

Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

1993 • 283 citations

Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

1988 • 260 citations

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

1992 • 255 citations

In situ demonstration of Epstein-Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site

1993 • 252 citations

Burkitt's Lymphoma

1981 • 236 citations

Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma

1987 • 228 citations

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

1991 • 216 citations

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

1992 • 214 citations

Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype.

1987 • 209 citations

Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.

1991 • 204 citations

Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire

1992 • 190 citations

The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining

1986 • 184 citations

The Development of B Cells and the B‐Cell Repertoire in the Microenvironment of the Germinal Center

1992 • 148 citations

Cloning and sequencing of human immunoglobulin _λ. gene segments

1993 • 145 citations

Molecular epidemiology of Burkitt's lymphoma from South America: differences in breakpoint location and Epstein-Barr virus association from tumors in other world regions

1992 • 138 citations

Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma

1995 • 129 citations

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

1995 • 114 citations

Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.

1982 • 112 citations

Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes

1994 • 111 citations

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.

1995 • 103 citations

Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

1995 • 98 citations

Epstein‐Barr virus status and tumour cell phenotype in sporadic Burkitt's lymphoma

1986 • 96 citations

Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia

1980 • 88 citations

Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments

1994 • 81 citations

Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment.

1993 • 78 citations

Burkitt-type lymphoma in France among non-Hodgkin malignant lymphomas in Caucasian children

1982 • 67 citations

A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma.

1994 • 67 citations

B cells of chronic lymphatic leukemia express V genes in unmutated form

1991 • 61 citations

IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation analysis [published erratum appears in Blood 1994 Aug 1;84(3):995]

1994 • 61 citations

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.

1994 • 55 citations

Differential usage of an Ig heavy chain variable region gene by human B- cell tumors

1993 • 49 citations

B-Cell Maturation Stages of Burkitt's Lymphoma Cell Lines According to Epstein-Barr Virus Status and Type of Chromosome Translocation<xref ref-type="fn" rid="FN2">2</xref>

1987 • 31 citations

Pattern of usage of the VH4–21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching

1995 • 20 citations

Recurrent mutation of immunoglobulin and c‐myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a burkitt lymphoma

1990 • 16 citations

Biased utilization of immunoglobulin variable region heavy‐ and light‐chain genes by the malignant CD5‐ B lymphocytes from patients with Burkitt's lymphoma

1994 • 13 citations

Immunoglobulin light chain transcripts with altered V regions in Burkitt's lymphoma cell lines producing short μ chains

1990 • 10 citations

Burkitt-like lymphoma in an English child: Characterisation of tumour biopsy cells and of the derived tumour cell line

1986 • 5 citations