Mnt: A Novel Max-interacting Protein and Myc Antagonist

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

1993 • 786 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1995 • 587 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

1993 • 536 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Myc and Max associate in vivo.

1992 • 428 citations

An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

1995 • 372 citations

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

1992 • 365 citations

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

1992 • 314 citations

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

1993 • 294 citations

Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.

1997 • 248 citations

Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse

1993 • 206 citations

Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus

1993 • 193 citations

A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.

1992 • 189 citations

Opposite regulation of gene transcription and cell proliferation by c-Myc and Max.

1993 • 146 citations

Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis.

1995 • 146 citations

Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

1994 • 125 citations

Sequence-Specific Transcriptional Activation by Myc and Repression by Max

1993 • 124 citations

Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions.

1995 • 61 citations

Sequence-specific transcriptional activation by Myc and repression by Max.

1993 • 61 citations

The Max Transcription Factor Network: Involvement of Mad in Differentiation and an Approach to Identification of Target Genes

1994 • 53 citations