Insight into Burkitt's Lymphoma from Immunoglobulin Variable Region Gene Analysis

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

A sarcoma involving the jaws in african children

1958 • 1,307 citations

Non-Hodgkin's Lymphoma in 90 Homosexual Men

1984 • 975 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

The Pathogenesis of Burkitt's Lymphoma

1990 • 477 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma.

1986 • 371 citations

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma

1983 • 286 citations

Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

1993 • 283 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

1988 • 260 citations

Non-Endemic Burkitt's Lymphoma

1976 • 257 citations

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

1992 • 255 citations

In situ demonstration of Epstein-Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site

1993 • 252 citations

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

1988 • 245 citations

A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q

1994 • 243 citations

Differential Rates of Somatic Hypermutation in VH Genes Among Subsets of Chronic Lymphocytic Leukemia Defined by Chromosomal Abnormalities

1997 • 237 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma

1987 • 228 citations

Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

1988 • 224 citations

Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle

1994 • 187 citations

Somatic hypermutation in low-grade mucosa-associated lymphoid tissue- type B-cell lymphoma

1995 • 182 citations

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.

1992 • 167 citations

Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression

1997 • 145 citations

Ongoing Ig Gene Hypermutation in Salivary Gland Mucosa-Associated Lymphoid Tissue-Type Lymphomas

1997 • 144 citations

Induction of Somatic Mutation in a Human B Cell Line In Vitro

1997 • 141 citations

Molecular epidemiology of Burkitt's lymphoma from South America: differences in breakpoint location and Epstein-Barr virus association from tumors in other world regions

1992 • 138 citations

Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma

1995 • 129 citations

Childhood non-Hodgkin lymphomas in the United Kingdom: findings from the UK Children's Cancer Study Group.

1997 • 124 citations

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

1995 • 114 citations

Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes

1994 • 111 citations

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection

1996 • 109 citations

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.

1995 • 103 citations

Ig VH gene expression among human follicular lymphomas

1991 • 101 citations

Identification of normal B‐cell counterparts of neoplastic cells which secrete cold agglutinins of anti‐I and anti‐i specificity

1989 • 101 citations

Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

1995 • 98 citations

Epstein‐Barr virus status and tumour cell phenotype in sporadic Burkitt's lymphoma

1986 • 96 citations

Burkitt's Lymphoma: A Human Cancer Model

1986 • 83 citations

A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest [published erratum appears in Blood 1991 Oct 1;78(7):1899]

1991 • 82 citations

Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments

1994 • 81 citations

Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment.

1993 • 78 citations

Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

1995 • 75 citations

A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma.

1994 • 67 citations

IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation analysis [published erratum appears in Blood 1994 Aug 1;84(3):995]

1994 • 61 citations

Follicular lymphoma immunoglobulin κ light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains

1997 • 61 citations

V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity

1993 • 60 citations

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.

1994 • 55 citations

Differential usage of an Ig heavy chain variable region gene by human B- cell tumors

1993 • 49 citations

Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma.

1989 • 48 citations

Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma

1996 • 45 citations

Selective variations in vivo of V_H3 and V_H1 gene family expression in peripheral B cell IgM, IgD and IgG during HIV infection

1995 • 43 citations

Burkitt's lymphoma outside the known endemic areas of Africa and New Guinea

1967 • 42 citations

VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease.

1993 • 41 citations

Favored use of immunoglobulin V(H)4 Genes in AIDS-associated B-cell lymphoma

1996 • 29 citations

Analysis of Immunoglobulin V_H Gene Repertoire by an Anchored PCR‐Elisa^a

1995 • 29 citations

Differential Usage of an Autoantibody-associated V_HGene, V_H4-21, by Human B-cell Tumors

1995 • 25 citations

Favored use of immunoglobulin V(H)4 Genes in AIDS-associated B-cell lymphoma

1996 • 22 citations

Complete nucleotide sequence of ig v genes in three cases of burkitt lymphoma associated with AIDS

1996 • 20 citations

Recurrent mutation of immunoglobulin and c‐myc genes and differential expression of cell surface antigens occur in variant cell lines derived from a burkitt lymphoma

1990 • 16 citations

Biased utilization of immunoglobulin variable region heavy‐ and light‐chain genes by the malignant CD5‐ B lymphocytes from patients with Burkitt's lymphoma

1994 • 13 citations

The Absence of Ongoing Immunoglobulin Gene Hypermutation Suggests a Distinct Mechanism for c-myc Mutation in Endemic Burkittʼs Lymphoma

1996 • 6 citations

Immunoglobulin heavy chain variable gene utilization in human large cell and Burkitt's lymphoma cell lines.

1994 • 6 citations

INVOLVEMENT OF THE JAWS IN BURKITT'S TUMOUR

1963 • 5 citations