Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.

1993 • 778 citations

Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.

1987 • 735 citations

A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.

1984 • 685 citations

Genetic analysis of immortalizing functions of Epstein–Barr virus in human B lymphocytes

1989 • 553 citations

Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region

1985 • 502 citations

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1989 • 497 citations

Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

1989 • 491 citations

A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.

1985 • 442 citations

Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation

1993 • 392 citations

trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.

1986 • 363 citations

The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication

1989 • 310 citations

Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells.

1985 • 277 citations

Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes

1992 • 258 citations

A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection

1989 • 254 citations

Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6

1990 • 249 citations

The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation

1991 • 238 citations

A subpopulation of normal B cells latently infected with Epstein-Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1

1995 • 220 citations

Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus

1989 • 217 citations

Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype.

1987 • 209 citations

Functional domains of Epstein-Barr virus nuclear antigen EBNA-1

1991 • 205 citations

An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene

1995 • 185 citations

A Putative Origin of Replication of Plasmids Derived from Epstein-Barr Virus Is Composed of Two cis-Acting Components

1985 • 182 citations

trans Activation of an Epstein-Barr Viral Transcriptional Enhancer by the Epstein-Barr Viral Nuclear Antigen 1

1986 • 176 citations

Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA

1990 • 164 citations

Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site.

1991 • 153 citations

The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated

1992 • 129 citations

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

1987 • 129 citations

Mapping Genetic Elements of Epstein-Barr Virus That Facilitate Extrachromosomal Persistence of Epstein-Barr Virus-Derived Plasmids in Human Cells

1985 • 119 citations

Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes.

1991 • 109 citations

Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites

1989 • 107 citations

An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.

1990 • 84 citations

Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication

1989 • 77 citations

EBNA-1, the major nuclear antigen of Epstein-Barr virus, resembles ‘RGG’ RNA binding proteins.

1994 • 75 citations

The Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic Mice

1992 • 62 citations

Transcription of the Epstein-Barr virus gene EBNA-1 from different promoters in nasopharyngeal carcinoma and B-lymphoblastoid cells

1992 • 60 citations

Expression of recombination activating genes (RAG-1 and RAG-2) in Epstein-Barr virus-bearing B cells [see comments]

1995 • 56 citations

Characterization of the Epstein-Barr virus Fp promoter

1995 • 28 citations

Structure of the Epstein-Barr virus nuclear antigen as probed with monoclonal antibodies

1985 • 20 citations

Delineation of a 16 Amino Acid Sequence That Forms a Core DNA Recognition Motif in the Epstein-Barr Virus EBNA-1 Protein

1994 • 19 citations