Trans-acting factors regulate the expression of CD44 splice variants.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

CD44 and Its Interaction with Extracellular Matrix

1993 • 1,082 citations

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

1992 • 1,040 citations

Cytoplasmic activation of human nuclear genes in stable heterocaryons

1983 • 839 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

CD44: The hyaluronan receptor

1992 • 610 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression

1994 • 436 citations

Expression and modulation of CD44 variant isoforms in humans

1994 • 436 citations

Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

1992 • 417 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.

1993 • 352 citations

CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.

1991 • 347 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

Splicing choice from ten variant exons establishes CD44 variability

1993 • 291 citations

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

1995 • 282 citations

Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing

1994 • 261 citations

Development and Biologic Properties of Malignant Cell Sublines and Clones of a Spontaneously Metastasizing Rat Mammary Adenocarcinoma<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 253 citations

The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat

1993 • 247 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

CD44: A Multitude of Isoforms with Diverse Functions

1993 • 229 citations

The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms.

1991 • 224 citations

The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior.

1993 • 223 citations

Polypurine sequences within a downstream exon function as a splicing enhancer.

1994 • 222 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

1992 • 171 citations

Synergistic interactions between two distinct elements of a regulated splicing enhancer.

1995 • 156 citations

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

1992 • 154 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

1991 • 146 citations

Somatic cell hybridization

1975 • 121 citations

Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences.

1989 • 97 citations

A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA.

1994 • 95 citations

A PCR-based method for the analysis of human CD44 splice products.

1993 • 92 citations

Characterization of BSp73, a spontaneous rat tumor and its in vivo selected variants showing different metastasizing capacities.

1983 • 90 citations

Exon as well as Intron Sequences Are cis-Regulating Elements for the Mutually Exclusive Alternative Splicing of the β Tropomyosin Gene

1990 • 87 citations

Splicing of pre-mRNA: mechanism, regulation and role in development

1993 • 86 citations

Polypurine Sequences within a Downstream Exon Function as a Splicing Enhancer

1994 • 85 citations

Transitions from high to low molecular weight isoforms of CD45 (T200) involve rapid activation of alternate mRNA splicing and slow turnover of surface CD45R.

1989 • 70 citations

Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP

1992 • 64 citations

The CD44 Proteins in Embryonic Development and in Cancer

1996 • 63 citations

Trans-acting factors regulate the expression of CD44 splice variants.

1996 • 53 citations

In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron.

1992 • 51 citations

Alternative Processing of Bovine Growth Hormone mRNA Is Influenced by Downstream Exon Sequences

1989 • 50 citations

Alternative Splicing of a Human α-Tropomyosin Muscle-Specific Exon: Identification of Determining Sequences

1992 • 47 citations

Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes.

1992 • 47 citations

The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors.

1992 • 45 citations

cis-acting sequences involved in exon selection in the chicken beta-tropomyosin gene.

1992 • 36 citations

Exon as well as intron sequences are cis-regulating elements for the mutually exclusive alternative splicing of the beta tropomyosin gene.

1990 • 28 citations

CD44 splice variants; expression on lymphocytes and in neoplasia

1993 • 25 citations

Identification of cis-Acting Intron and Exon Regions in Influenza Virus NS1 mRNA That Inhibit Splicing and Cause the Formation of Aberrantly Sedimenting Presplicing Complexes

1992 • 18 citations

cis-Acting Sequences Involved in Exon Selection in the Chicken β-Tropomyosin Gene

1992 • 13 citations

The privilege of expressing CD44v - used by immune cells, misused by tumour cells

1996 • 1 citations