The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

The isolation and characterization of the human suppressor inducer T cell subset.

1985 • 860 citations

Human naive and memory T cells

1988 • 793 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.

1986 • 515 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Demonstration that the leukocyte common antigen (CD45) is a protein tyrosine phosphatase

1988 • 425 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.

1987 • 327 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Structural variants of human T200 glycoprotein (leukocyte-common antigen).

1987 • 239 citations

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

1989 • 238 citations

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

1988 • 223 citations

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

1984 • 221 citations

Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

1988 • 218 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation.

1988 • 213 citations

Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.

1989 • 196 citations

Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene.

1991 • 186 citations

Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line.

1991 • 186 citations

Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL 2 receptor expression.

1985 • 164 citations

Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus.

1987 • 159 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.

1991 • 146 citations

Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.

1985 • 145 citations

Characterization of CD45 and CD45R monoclonal antibodies using transfected mouse cell lines that express individual human leukocyte common antigens.

1988 • 140 citations

Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons

1987 • 126 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

Complete exon-intron organization of the human leukocyte common antigen (CD45) gene.

1988 • 107 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch.

1990 • 97 citations

The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells.

1986 • 94 citations

Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression.

1985 • 84 citations

Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.

1987 • 82 citations

Transitions from high to low molecular weight isoforms of CD45 (T200) involve rapid activation of alternate mRNA splicing and slow turnover of surface CD45R.

1989 • 70 citations

Cell-type-specific expression of alternatively spliced human fibronectin IIICS mRNAs.

1990 • 65 citations

Lymphokine regulation of CD45R expression on human T cell clones.

1989 • 61 citations

CD4+CD45RA+ and CD4+CD45RA− T cell subsets in man maintain distinct function and CD45RA expression persists on a subpopulation of CD45RA+ cells after activation with Con A

1990 • 51 citations

Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons.

1988 • 50 citations

A human leukocyte antigen identified by a monoclonal antibody

1981 • 49 citations

Novel antigenic determinants of the T200 glycoprotein expressed preferentially by activated cytotoxic T lymphocytes.

1985 • 47 citations

Selective blockade of human natural killer cells by a monoclonal antibody.

1982 • 39 citations

Developmental expression of CD45 alternate exons in murine T cells. Evidence of additional alternate exon use.

1991 • 38 citations

T200 alternate exon use in murine lymphoid cells determined by reverse transcription-polymerase chain reaction.

1989 • 37 citations

Integrity of the Exon 6 Sequence Is Essential for Tissue-Specific Alternative Splicing of Human Leukocyte Common Antigen Pre-mRNA

1989 • 34 citations

Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system

1989 • 32 citations

Regulation of alternative splicing in the generation of isoforms of the mouse Ly-5 (CD45) glycoprotein.

1990 • 29 citations

Accurate 5' splice-site selection in mouse kappa immunoglobulin light chain premessenger RNAs is not cell-type-specific.

1987 • 22 citations

Further data on the selective expression of Ly-5 isoforms

1990 • 19 citations

Comparison of in vitro and in vivo splice site selection in kappa-immunoglobulin precursor mRNA.

1988 • 17 citations