The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Integrins.

1991 • 1,369 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.

1985 • 517 citations

The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.

1988 • 446 citations

Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule

1981 • 444 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.

1985 • 335 citations

Development of cell surface linkage complexes in cultured fibroblasts.

1985 • 320 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

Integrins and tumor cell dissemination.

1989 • 294 citations

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.

1992 • 292 citations

The interaction of plasma fibronectin with fibroblastic cells in suspension.

1985 • 266 citations

A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.

1993 • 264 citations

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.

1990 • 251 citations

Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies.

1990 • 231 citations

Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation.

1988 • 228 citations

Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.

1987 • 223 citations

Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction.

1991 • 196 citations

A fibronectin self-assembly site involved in fibronectin matrix assembly: reconstruction in a synthetic peptide.

1992 • 169 citations

A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

1989 • 167 citations

Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrins [published erratum appears in J Cell Biol 1992 Jul;118(1):217]

1992 • 143 citations

Role of the I-9 and III-1 modules of fibronectin in formation of an extracellular fibronectin matrix

1991 • 137 citations

Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor.

1989 • 135 citations

Increased tumorigenicity of fibronectin receptor deficient Chinese hamster ovary cell variants.

1991 • 133 citations

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v.

1990 • 80 citations

Mechanisms for organization of fibronectin matrix

1990 • 23 citations