Role of the retinoblastoma protein in the pathogenesis of human cancer.

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Retinoblastoma: Clues to Human Oncogenesis

1984 • 495 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

1996 • 404 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

1997 • 386 citations

Gene for Hereditary Retinoblastoma Assigned to Human Chromosome 13 by Linkage to Esterase D

1983 • 369 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

1993 • 347 citations

Patient with 13 Chromosome Deletion: Evidence That the Retinoblastoma Gene Is a Recessive Cancer Gene

1983 • 342 citations

Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

1995 • 339 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.

1996 • 267 citations

RB kinases and RB-binding proteins: new points of view

1997 • 264 citations

The transcription factor E2F is required for S phase during Drosophila embryogenesis.

1995 • 259 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter

1996 • 248 citations

Mutation spectrum of the retinoblastoma gene in osteosarcomas.

1994 • 248 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

1988 • 247 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

1983 • 234 citations

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.

1994 • 221 citations

The retinoblastoma gene is involved in malignant progression of astrocytomas

1994 • 220 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

1988 • 204 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

Retinoblastoma: a prototypic hereditary neoplasm.

1978 • 197 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

The Transcription Factor E2F-1 Is a Downstream Target of RB Action

1995 • 190 citations

Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.

1991 • 184 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.

1991 • 177 citations

Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma.

1994 • 170 citations

Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector

1997 • 168 citations

Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas

1992 • 167 citations

Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines.

1995 • 166 citations

Unrestricted cell cycling and cancer

1995 • 164 citations

Molecular characterization of the retinoblastoma susceptibility gene

1993 • 161 citations

Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

1993 • 159 citations

Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer

1991 • 158 citations

Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis

1994 • 149 citations

An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

1987 • 149 citations

Transcriptional control by E2F

1995 • 147 citations

Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma.

1994 • 146 citations

Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression

1993 • 140 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Evidence for a new tumour suppressor locus (DBM) in human B–cell neoplasia telomeric to the retinoblastoma gene

1993 • 135 citations

Spectrum of germline mutations in the RB1 gene: a study of 232 patients with hereditary and non hereditary retinoblastoma

1995 • 131 citations

Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

1995 • 129 citations

Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group.

1993 • 128 citations

The retinoblastoma gene in human pituitary tumors.

1993 • 127 citations

Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers.

1991 • 123 citations

Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas.

1993 • 118 citations

Analysis of Alterations in the Retinoblastoma Gene and Tumor Grade in Bone and Soft-Tissue Sarcomas

1991 • 115 citations

The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter

1995 • 115 citations

Variable mutations of the RB gene in small-cell lung carcinoma.

1990 • 105 citations

Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus.

1993 • 102 citations

Studies of the retinoblastoma gene in human sarcomas.

1989 • 100 citations

Retinoblastoma gene mutations in primary human prostate cancer

1995 • 99 citations

Inactivation of the retinoblastoma gene in human lymphoid neoplasms

1991 • 91 citations

Deletion of the retinoblastoma gene in multiple myeloma.

1994 • 90 citations

Retinoblastoma gene deletions in human glioblastomas.

1991 • 89 citations

Retinoblastoma gene mutations in primary human bladder cancer

1995 • 88 citations

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

1995 • 85 citations

Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas

1996 • 84 citations

Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.

1994 • 84 citations

Differential Inactivation of CDKN2 and Rb Protein in Non--Small-Cell and Small-Cell Lung Cancer Cell Lines

1995 • 82 citations

Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus.

1994 • 79 citations

Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.

1994 • 77 citations

Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function

1996 • 72 citations

The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene.

1993 • 68 citations

Loss of heterozygosity at the RB locus correlates with loss of RB protein in primary malignant neuro‐endocrine lung carcinomas

1994 • 67 citations

Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization.

1995 • 66 citations

Deletion of the human retinoblastoma gene in primary leukemias

1990 • 64 citations

Allele Loss at the Retinoblastoma Locus in Human Ovarian Cancer

1991 • 61 citations

Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia.

1994 • 59 citations

Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations.

1993 • 57 citations

An E2F dominant negative mutant blocks E1A induced cell cycle progression.

1994 • 55 citations

An analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma

1990 • 55 citations

Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer

1995 • 50 citations

Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors

1996 • 49 citations

Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells

1994 • 47 citations

High incidence of deletions but infrequent inactivation of the retinoblastoma gene in human myeloma cells

1995 • 42 citations

xRB as a modulator of transcription

1996 • 42 citations

Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction.

1996 • 41 citations

Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma

1995 • 37 citations

The Retinoblastoma Gene (RB-1) Status in Multiple Myeloma: A Report on 35 Cases

1995 • 36 citations

Lack of expression of tumor-suppressor genes in human malignant glioma cell lines.

1992 • 34 citations

THE RETINOBLASTOMA GENE (RB1) IN ACUTE MYELOID LEUKAEMIA: ANALYSIS OF GENE REARRANGEMENTS, PROTEIN EXPRESSION AND COMPARISON OF DISEASE OUTCOME

1996 • 27 citations

Retinoblastoma Protein Expression in Endometrial Hyperplasia and Carcinoma

1997 • 21 citations

Retinoblastoma gene structure and product expression in human gastric carcinomas

1994 • 16 citations

Expression of the retinoblastoma gene product in renal tumors.

1996 • 13 citations

Nasopharyngeal carcinoma and retinoblastoma gene expression.

1992 • 10 citations

Retinoblastoma gene mutation in primary human renal cell carcinoma.

1995 • 3 citations