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Functional rafts in cell membranes

1997 • 9,471 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

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1989 • 5,116 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

LAT

1998 • 1,251 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

2001 • 1,082 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

The Immunological Synapse

2001 • 987 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Extraction of Cholesterol with Methyl-β-Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles

1999 • 970 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.

1994 • 912 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE

1955 • 791 citations

Regulated internalization of caveolae.

1994 • 760 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes

1997 • 661 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

1995 • 597 citations

Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy

1998 • 590 citations

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

2000 • 572 citations

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

1996 • 566 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane

2000 • 557 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Flotillin and Epidermal Surface Antigen Define a New Family of Caveolae-associated Integral Membrane Proteins

1997 • 549 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Reduction of caveolin and caveolae in oncogenically transformed cells.

1995 • 505 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization

2001 • 487 citations

Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 • 475 citations

A Role for Lipid Rafts in B Cell Antigen Receptor Signaling and Antigen Targeting

1999 • 473 citations

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1998 • 473 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

1999 • 456 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

2000 • 452 citations

Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae.

1994 • 449 citations

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1998 • 435 citations

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

1998 • 415 citations

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

1999 • 402 citations

Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border

1998 • 389 citations

Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth

2000 • 379 citations

Localization of Platelet-derived Growth Factor-stimulated Phosphorylation Cascade to Caveolae

1996 • 378 citations

Recombinant Expression of Caveolin-1 in Oncogenically Transformed Cells Abrogates Anchorage-independent Growth

1997 • 377 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.

1992 • 369 citations

Localization of the insulin receptor in caveolae of adipocyte plasma membrane

1999 • 364 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBE

1995 • 362 citations

Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains

1997 • 353 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

1993 • 350 citations

Purification and characterization of smooth muscle cell caveolae.

1994 • 347 citations

Apolipoprotein-mediated removal of cellular cholesterol and phospholipids

1996 • 346 citations

Cellular isoform of the scrapie agent protein participates in lymphocyte activation

1990 • 342 citations

Elevated expression of caveolin is associated with prostate and breast cancer.

1998 • 336 citations

Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes

1999 • 327 citations

Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells

1999 • 322 citations

Involvement of Cellular Caveolae in Bacterial Entry into Mast Cells

2000 • 317 citations

Regulated Migration of Epidermal Growth Factor Receptor from Caveolae

1999 • 314 citations

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

1993 • 307 citations

Regulation of caveolin and caveolae by cholesterol in MDCK cells

1998 • 307 citations

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

2000 • 307 citations

Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells

1998 • 303 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

2000 • 295 citations

Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.

1995 • 294 citations

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

1999 • 294 citations

Released GFRα1 Potentiates Downstream Signaling, Neuronal Survival, and Differentiation via a Novel Mechanism of Recruitment of c-Ret to Lipid Rafts

2001 • 289 citations

Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry

1999 • 288 citations

Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling

1998 • 284 citations

Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth

1999 • 281 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

Cellular aspects of transcapillary exchange

1983 • 277 citations

Organized Endothelial Cell Surface Signal Transduction in Caveolae Distinct from Glycosylphosphatidylinositol-anchored Protein Microdomains

1997 • 274 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains

1998 • 254 citations

Differential Targeting of Shaker-like Potassium Channels to Lipid Rafts

2000 • 249 citations

Tyrosine Kinase Receptors Concentrated in Caveolae-like Domains from Neuronal Plasma Membrane

1997 • 248 citations

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.

1996 • 246 citations

Myristoylation and Differential Palmitoylation of the HCK Protein-Tyrosine Kinases Govern Their Attachment to Membranes and Association with Caveolae

1995 • 237 citations

COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

1997 • 232 citations

Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner

2000 • 227 citations

A Novel Functional Interaction between Vav and PKCθ Is Required for TCR-Induced T Cell Activation

2000 • 226 citations

Interactions between FcεRI and lipid raft components are regulated by the actin cytoskeleton

2000 • 225 citations

The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles

1992 • 223 citations

Cholesterol and caveolae: structural and functional relationships

2000 • 222 citations

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

1997 • 221 citations

Observing Fcεri Signaling from the Inside of the Mast Cell Membrane

2000 • 219 citations

The Actin Cytoskeleton and Lymphocyte Activation

1999 • 218 citations

Insulin stimulates the tyrosine phosphorylation of caveolin.

1995 • 215 citations

Flotillins/Cavatellins Are Differentially Expressed in Cells and Tissues and Form a Hetero-oligomeric Complex with Caveolins in Vivo

1999 • 208 citations

The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae.

1995 • 196 citations

Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae).

1997 • 195 citations

The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells.

1992 • 191 citations

Annexin V Binds to Viable B Cells and Colocalizes with a Marker of Lipid Rafts upon B Cell Receptor Activation

2000 • 188 citations

The Eph family in retinal axon guidance

1997 • 187 citations

Plasmalemmal caveolae and GPI-anchored membrane proteins

1993 • 186 citations

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcϵRI and LAT

2001 • 177 citations

GDNF triggers a novel Ret‐independent Src kinase family‐coupled signaling via a GPI‐linked GDNF receptor α1

1999 • 175 citations

Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

1996 • 172 citations

Cancer-Associated Glycosphingolipid Antigens: Their Structure, Organization, and Function

1998 • 163 citations

Epstein–Barr Virus Coopts Lipid Rafts to Block the Signaling and Antigen Transport Functions of the BCR

2001 • 159 citations

Reduction of Caveolin 1 Gene Expression in Lung Carcinoma Cell Lines

1999 • 159 citations

Tissue expression, structure and function of the murine Ly‐6 family of molecules

1995 • 159 citations

Glycosphingolipids Are Not Essential for Formation of Detergent-resistant Membrane Rafts in Melanoma Cells

1999 • 159 citations

Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells

1998 • 159 citations

Caveolae, Plasma Membrane Microdomains for α-Secretase-mediated Processing of the Amyloid Precursor Protein

1998 • 157 citations

Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts

2001 • 155 citations

Rapid Redistribution of CD20 to a Low Density Detergent-insoluble Membrane Compartment

1998 • 150 citations

Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk

2000 • 145 citations

Involvement of Gangliosides in Glycosylphosphatidylinositol-anchored Neuronal Cell Adhesion Molecule TAG-1 Signaling in Lipid Rafts

2000 • 145 citations

Association of GAP-43 with Detergent-resistant Membranes Requires Two Palmitoylated Cysteine Residues

1998 • 144 citations

Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains

1999 • 143 citations

Enhanced myogenesis in NCAM-transfected mouse myoblasts

1990 • 141 citations

Calcium signal transduction from caveolae

1999 • 140 citations

GDNF – a stranger in the TGF‐β superfamily?

2000 • 139 citations

Signal Transduction Through Glyco(sphingo)lipids: Introduction and Recent Studies on Glyco(sphingo)lipid‐enriched Microdomains^a

1998 • 137 citations

Transient Translocation of the B Cell Receptor and Src Homology 2 Domain-Containing Inositol Phosphatase to Lipid Rafts: Evidence Toward a Role in Calcium Regulation

2000 • 136 citations

A Balance between Positive and Negative Signals in Cytotoxic Lymphocytes Regulates the Polarization of Lipid Rafts during the Development of Cell-Mediated Killing

2000 • 134 citations

Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

1989 • 126 citations

A requirement for lipid rafts in B cell receptor induced Ca 2+ flux

2000 • 125 citations

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

1999 • 124 citations

GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking.

1996 • 121 citations

Role for lipid rafts in regulating interleukin-2 receptor signaling

2001 • 121 citations

Cutting Edge: B Cell Antigen Receptor Signaling Occurs Outside Lipid Rafts in Immature B Cells

2000 • 117 citations

Agonist-induced redistribution of bradykinin B 2 receptor in caveolae

1998 • 116 citations

Immunoisolation of Caveolae with High Affinity Antibody Binding to the Oligomeric Caveolin Cage

1999 • 116 citations

Urokinase-Type Plasminogen Activator Binding to Its Receptor Stimulates Tumor Cell Migration by Enhancing Integrin-Mediated Signal Transduction

1999 • 112 citations

Identification of a Cytoplasmic Region of CD20 Required for Its Redistribution to a Detergent-Insoluble Membrane Compartment

1998 • 110 citations

Compartmentation of Cyclic Adenosine 3′,5′-Monophosphate Signaling in Caveolae

1999 • 109 citations

Phosphatidylinositol 4-Phosphate Synthesis in Immunoisolated Caveolae-like Vesicles and Low Buoyant Density Non-caveolar Membranes

1998 • 108 citations

Dual Fatty Acylation of p59Fyn Is Required for Association with the T Cell Receptor ζ Chain through Phosphotyrosine–Src Homology Domain-2 Interactions

1999 • 105 citations

Structural Aspects of the Association of FcεRI with Detergent-resistant Membranes

1999 • 105 citations

Resistance to apoptosis caused byPIG-Agene mutations in paroxysmal nocturnal hemoglobinuria

1997 • 105 citations

Insulin-Stimulated Glucose Uptake Involves the Transition of Glucose Transporters to a Caveolae-Rich Fraction within the Plasma Membrane: Implications for Type II Diabetes

1996 • 102 citations

The amplification of TCR signaling by dynamic membrane microdomains

2001 • 100 citations

Heparan sulfate proteoglycans as transducers of FGF-2 signalling

1994 • 94 citations

Epidermal Growth Factor-stimulated Tyrosine Phosphorylation of Caveolin-1

2000 • 94 citations

Each Caveola Contains Multiple Glycosyl-phosphatidylinositol-anchored Membrane Proteins

1992 • 91 citations

Exogenous Administration of Gangliosides Displaces GPI-anchored Proteins from Lipid Microdomains in Living Cells

1999 • 91 citations

Detergent-resistant membrane microdomains from Caco-2 cells do not contain caveolin

1996 • 87 citations

Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts.

1993 • 81 citations

Evidence that ganglioside enriched domains are distinct from caveolae in MDCK II and human fibroblast cells in culture

2000 • 81 citations

Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidelinositol‐anchored antigens

1993 • 80 citations

Tandem Duplication of rab Genes Followed by Sequence Divergence and Acquisition of Distinct Functions in Trypanosoma brucei

1997 • 79 citations

Differential Effects of Filipin and Methyl-β-cyclodextrin on B Cell Receptor Signaling

2001 • 75 citations

Requirement of Caveolae Microdomains in Extracellular Signal‐Regulated Kinase and Focal Adhesion Kinase Activation Induced by Endothelin‐1 in Primary Astrocytes

1999 • 72 citations

Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation

2001 • 70 citations

Insulin second messengers

1997 • 69 citations

T Cell Signalling Through CD73

1997 • 65 citations

Membrane lipid microdomains and the role of PKCθ in T cell activation

2001 • 65 citations

Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains.

1996 • 65 citations

Deletion of Bone Marrow Stromal Cell Antigen-1 (CD157) Gene Impaired Systemic Thymus Independent-2 Antigen-Induced IgG3 and Mucosal TD Antigen-Elicited IgA Responses

1998 • 63 citations

Antibody Cross-linking of the Glycosylphosphatidylinositol-linked Protein CD59 on Hematopoietic Cells Induces Signaling Pathways Resembling Activation by Complement

1998 • 60 citations

Expression of Caveolin-1 in Human T Cell Leukemia Cell Lines

1998 • 60 citations

T Cell Receptor Signalling Results in Rapid Tyrosine Phosphorylation of the Linker Protein LAT Present in Detergent-Resistant Membrane Microdomains

1998 • 58 citations

The association of the protein tyrosine kinases p56^lck and p60^fyn with the glycosyl phosphatidylinositol‐anchored proteins Thy‐1 and CD48 in rat thymocytes is dependent on the state of cellular activation

1993 • 58 citations

Human BST-1 Expressed on Myeloid Cells Functions as a Receptor Molecule

1996 • 57 citations

Changes in membrane microdomains and caveolae constituents in multidrug‐resistant cancer cells

1999 • 57 citations

Loss of functional caveolae during senescence of human fibroblasts

2001 • 53 citations

Insulin stimulates the release of the glycosyl phosphatidylinositol-anchored membrane dipeptidase from 3T3-L1 adipocytes through the action of a phospholipase C

1997 • 53 citations

Mouse CD24 as a Signaling Molecule for Integrin-Mediated Cell Binding: Functional and Physical Association with src-Kinases

1997 • 52 citations

The Specificity for the Differentiation Blocking Activity of Carcinoembryonic Antigen Resides in Its Glycophosphatidyl-Inositol Anchor

2000 • 52 citations

Basic fibroblast growth factor (FGF-2) is addressed to caveolae after binding to the plasma membrane of BHK cells.

1996 • 49 citations

Spatial Organization of EGF Receptor Transmodulation by PDGF

1999 • 47 citations

Signaling Within a Caveolae‐Like Membrane Microdomain in Human Neuroblastoma Cells in Response to Fibroblast Growth Factor

2000 • 41 citations

Compartmentation of Cyclic Adenosine 3',5'-Monophosphate Signaling in Caveolae

1999 • 35 citations

Functional expression of the endogenous Thy‐1 gene and the transfected murine Thy‐1.2 gene in rat basophilic leukemia cells

1991 • 33 citations

Analysis of the domain requirement in Gas1 growth suppressing activity

2000 • 31 citations

Caveolar Structure and Protein Sorting Are Maintained in NIH 3T3 Cells Independent of Glycosphingolipid Depletion

2000 • 29 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in a rat mast cell line. Impairment of tyrosine kinase-dependent signal transduction and the subsequent degranulation response

1993 • 25 citations

A possible role for mono(ADP‐ribosyl)transferase in the signalling pathway mediating neutrophil chemotaxis

1996 • 16 citations

A Comparison of the Tolerability and Efficacy of Lovastatin 20 mg and Fluvastatin 20 mg in the Treatment of Primary Hypercholesterolemia

1996 • 12 citations