Changes in membrane microdomains and caveolae constituents in multidrug‐resistant cancer cells

Functional rafts in cell membranes

1997 • 9,471 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 • 783 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

1982 • 578 citations

Caveolae and caveolins

1996 • 549 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

Reduction of caveolin and caveolae in oncogenically transformed cells.

1995 • 505 citations

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1998 • 435 citations

Intracellular cholesterol transport

1999 • 416 citations

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

1998 • 415 citations

Recombinant Expression of Caveolin-1 in Oncogenically Transformed Cells Abrogates Anchorage-independent Growth

1997 • 377 citations

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 357 citations

Localization and Turnover of Phosphatidylinositol 4,5-Bisphosphate in Caveolin-enriched Membrane Domains

1996 • 354 citations

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

1996 • 347 citations

GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells

1998 • 303 citations

Up-regulation of Caveolae and Caveolar Constituents in Multidrug-resistant Cancer Cells

1998 • 298 citations

Intracellular cholesterol transport

1997 • 295 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Organized Endothelial Cell Surface Signal Transduction in Caveolae Distinct from Glycosylphosphatidylinositol-anchored Protein Microdomains

1997 • 274 citations

Plasma membrane caveolae mediate the efflux of cellular free cholesterol

1995 • 273 citations

Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

1997 • 256 citations

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.

1996 • 246 citations

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers

1997 • 241 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

Caveolae: Static inpocketings of the plasma membrane, dynamic vesicles or plain artifact?

1988 • 197 citations

The effects of lipids and detergents on ATPase-active P-glycoprotein

1993 • 186 citations

P-glycoprotein multidrug resistance and cancer

1996 • 180 citations

Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

1996 • 172 citations

Function, evolution and structure of multidrug resistance protein (MRP)

1997 • 168 citations

Structure and Function of Sphingoglycolipids in Transmembrane Signalling and Cell-Cell Interactions

1993 • 163 citations

Organization of lipids in the plasma membranes of malignant and stimulated cells: a new model

1988 • 158 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

Caveolae, transmembrane signalling and cellular transformation

1995 • 139 citations

[47] Caveolae purification and glycosylphosphatidylinositol-linked protein sorting in polarized epithelia

1995 • 123 citations

Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

1995 • 117 citations

Localization of Phospholipase D in Detergent-insoluble, Caveolin-rich Membrane Domains

1999 • 114 citations

Phosphatidylinositol 4-Phosphate Synthesis in Immunoisolated Caveolae-like Vesicles and Low Buoyant Density Non-caveolar Membranes

1998 • 108 citations

Activation of phospholipase D1 by direct interaction with ADP‐ribosylation factor 1 and RalA

1998 • 108 citations

Structure of the multidrug resistance P-glycoprotein

1997 • 107 citations

Compartmentalization of Phosphatidylinositol 4,5-Bisphosphate in Low-Density Membrane Domains in the Absence of Caveolin

1998 • 107 citations

Intracellular Transport of Low Density Lipoprotein Derived Free Cholesterol Begins at Clathrin-Coated Pits and Terminates at Cell Surface Caveolae

1996 • 98 citations

Purification and Characterization of a Novel Endopeptidase in Ragweed (Ambrosia artemisiifolia) Pollen

1996 • 94 citations

Signals Determining Protein Tyrosine Kinase and Glycosyl-Phosphatidylinositol-Anchored Protein Targeting to a Glycolipid-Enriched Membrane Fraction

1994 • 88 citations

Plasma membrane lipid composition of vinblastine sensitive and resistant human leukaemic lymphoblasts

1988 • 71 citations

Differences in lipid composition of doxorubicin-sensitive and -resistant P388 cells.

1984 • 62 citations

Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells

1993 • 59 citations

The effect of short‐term diets rich in fish, red meat, or white meat on thromboxane and prostacyclin synthesis in humans

1997 • 54 citations

Fatty acid composition transport and metabolism in doxorubicin-sensitive and-resistant rat glioblastoma cells.

1986 • 36 citations

Introduction: Multidrug resistant proteins

1997 • 35 citations

Fluorescence anisotropy of cell membranes of doxorubicin-sensitive and -resistant rodent tumoral cells.

1986 • 30 citations

Clinical drug resistance: The role of factors other than P-glycoprotein

1995 • 29 citations

Cytoplasmic membrane cholesterol and doxorubicin cytotoxicity in drug-sensitive and multidrug-resistant human ovarian cancer cells.

1993 • 28 citations

Partially Purified RhoA‐Stimulated Phospholipase D Activity Specifically Binds to Phosphatidylinositol 4,5‐Bisphosphate

1996 • 23 citations

Cell membrane fluidity and adriamycin retention in a tumor progression movel of AKR lymphoma

1996 • 21 citations

Ultraviolet Photolysis of Sodium Nitrate Solutions in the Laboratory and by Sunlight

1968 • 16 citations