Role for lipid rafts in regulating interleukin-2 receptor signaling

Lipid rafts and signal transduction

2000 • 6,079 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei.

1977 • 492 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions

1977 • 366 citations

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines

2000 • 363 citations

Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains

1997 • 353 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes

2000 • 338 citations

Cross Talk Between Interferon-γ and -α/β Signaling Components in Caveolar Membrane Domains

2000 • 316 citations

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.

1996 • 312 citations

GPI-microdomains: a role in signalling via immunoreceptors

1999 • 270 citations

Drug solubilizers to aid pharmacologists: Amorphous cyclodextrin derivatives

1988 • 235 citations

Observing Fcεri Signaling from the Inside of the Mast Cell Membrane

2000 • 219 citations

Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.

1995 • 206 citations

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase

1997 • 184 citations

Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts

2000 • 152 citations

Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the αβ T-cell receptor

1992 • 146 citations

Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2

2000 • 139 citations

Microdomain-dependent Regulation of Lck and Fyn Protein-Tyrosine Kinases in T Lymphocyte Plasma Membranes

1999 • 136 citations

Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study

1997 • 130 citations

The Interleukin 2 Receptor

1988 • 118 citations

Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of thePig-agene

1998 • 111 citations

Structural Aspects of the Association of FcεRI with Detergent-resistant Membranes

1999 • 105 citations

Large, detergent‐resistant complexes containing murine antigens Thy‐1 and Ly‐6 and protein tyrosine kinase p56^lck

1993 • 99 citations

Attenuation of Interleukin 2 Signal in the Spleen Cells of Complex Ganglioside-lacking Mice

1999 • 50 citations

Physical Association of CD4 and CD45 in Primary, Resting CD4+T Cells

1997 • 35 citations

Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function

1999 • 31 citations

The function of GPI-anchored proteins in T cell development, activation and regulation of homeostasis.

2000 • 27 citations

Palmitylation of Src Family Tyrosine Kinases Regulates Functional Interaction with a B Cell Substrate

1997 • 10 citations