Gli proteins encode context-dependent positive and negative functions: implications for development and disease

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Sonic hedgehog regulates the growth and patterning of the cerebellum

1999 • 903 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

1987 • 671 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

1997 • 633 citations

Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

1997 • 625 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3

1999 • 528 citations

GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome

1997 • 501 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

1998 • 449 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1998 • 419 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

1999 • 370 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Sonic hedgehog signaling by the Patched–Smoothened receptor complex

1999 • 326 citations

The GLI-Kruppel family of human genes.

1988 • 302 citations

Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning

1996 • 299 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

1997 • 275 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog

1998 • 243 citations

Gli/Zic factors pattern the neural plate by defining domains of cell differentiation

1998 • 233 citations

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development

1997 • 199 citations

Catching a Gli-mpse of Hedgehog

1997 • 198 citations

A duplicated zone of polarizing activity in polydactylous mouse mutants.

1995 • 189 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

GLI 3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization

1999 • 173 citations

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

1998 • 169 citations

Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice

1997 • 152 citations

Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

1997 • 149 citations

Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes

1997 • 140 citations

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.

1992 • 133 citations

Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation

1997 • 129 citations

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

1997 • 115 citations

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

1991 • 107 citations

Restrictions to Floor Plate Induction by hedgehog and Winged-Helix Genes in the Neural Tube of Frog Embryos

1995 • 107 citations

gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

1993 • 95 citations

Dual pathways for induction of wingless expression by protein kinase A and Hedgehog inDrosophila embryos

1997 • 80 citations

Conservation of the C.elegans tra-2 3'UTR translational control

1997 • 63 citations

Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression

1998 • 51 citations

Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome

1998 • 50 citations

A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm

1997 • 48 citations

The Zinc Finger Protein GLI Transforms Primary Cells in Cooperation with Adenovirus E1A

1991 • 40 citations

Cloning and Sequencing of the MouseGli2Gene: Localization to theDominant hemimeliaCritical Region

1997 • 34 citations

Deleted Work

1955 • 0 citations

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