Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria.

1983 • 1,661 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2

1990 • 498 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Effects of BMP-2, BMP-4, and BMP-6 on Osteoblastic Differentiation of Bone Marrow-Derived Stromal Cell Lines, ST2 and MC3T3-G2/PA6

1996 • 348 citations

Cellular and Molecular Biology of Bone

1993 • 249 citations

Human Osteogenic Protein-1 Induces Chondroblastic, Osteoblastic, and/or Adipocytic Differentiation of Clonal Murine Target Cells

1996 • 238 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-β superfamily

1995 • 137 citations

The hedgehog gene family in Drosophila and vertebrate development

1994 • 109 citations

BONE MORPHOGENETIC PROTEINS AND THEIR GENE EXPRESSION

1993 • 75 citations

Surgical Removal of Limb BudSonic hedgehogResults in Posterior Skeletal Defects

1996 • 53 citations

Dihydrocarveol

1979 • 5 citations