Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Patterning the Vertebrate Neuraxis

1996 • 1,151 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

1995 • 1,060 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Nested expression domains of four homeobox genes in developing rostral brain

1992 • 794 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

1987 • 671 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny

1981 • 497 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

1990 • 478 citations

Origins of the avian neural crest: the role of neural plate-epidermal interactions

1995 • 423 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

1996 • 351 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member

1993 • 320 citations

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

1996 • 320 citations

An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1

1994 • 306 citations

Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning

1996 • 299 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

Dorsalization of the neural tube by the non-neural ectoderm

1995 • 295 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system

1994 • 272 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system

1994 • 246 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Control of neuronal diversity by the floor plate: Contact-mediated induction of midbrain dopaminergic neurons

1995 • 229 citations

Drosophila Krüppel protein is a transcriptional represser

1990 • 228 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Amplification of the gli gene in childhood sarcomas.

1989 • 218 citations

Endohedral fullerene production

1996 • 198 citations

Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

1993 • 189 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate

1991 • 177 citations

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway

1996 • 176 citations

Concentration-dependent transcriptional activation or repression by Krüppel from a single binding site

1991 • 166 citations

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein

1995 • 162 citations

Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.

1994 • 115 citations

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

1991 • 107 citations

Dimerization and the control of transcription by Krüppel

1993 • 106 citations

Phosphorylation of the fused protein kinase in response to signaling from hedgehog.

1996 • 105 citations

Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)

1992 • 104 citations

Isthmic origin of neurons of the rat substantia nigra

1983 • 101 citations

Functional interactions between YY1 and adenovirus E1A

1995 • 84 citations

Genetic approaches to inflorescence and leaf development in maize

1991 • 65 citations

Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice

1996 • 55 citations

Surgical Removal of Limb BudSonic hedgehogResults in Posterior Skeletal Defects

1996 • 53 citations