Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.

1990 • 975 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Genome organization and transactivation of the human immunodeficiency virus type 2

1987 • 842 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.

1982 • 722 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein.

1990 • 360 citations

Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1

1989 • 294 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin.

1987 • 280 citations

Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus

1991 • 257 citations

Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies

1991 • 249 citations

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

1991 • 228 citations

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

1990 • 214 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

Generation of human monoclonal antibodies to human immunodeficiency virus.

1989 • 183 citations

HIV requires multiple gp120 molecules for CD4-mediated infection

1990 • 179 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4

1992 • 173 citations

Oligomeric organization of gp120 on infectious human immunodeficiency virus type 1 particles

1990 • 161 citations

Studies with crosslinking reagents on the oligomeric structure of the env glycoprotein of HIV

1989 • 160 citations

Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay

1990 • 153 citations

The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule

1988 • 144 citations

Enhancement of SIV Infection with Soluble Receptor Molecules

1990 • 136 citations

Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4.

1991 • 130 citations

Identification of Two Neutralizing and 8 Non-Neutralizing Epitopes on Simian Immunodeficiency Virus Envelope Using Monoclonal Antibodies

1992 • 103 citations

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1991 • 101 citations

Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody.

1991 • 99 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity.

1991 • 91 citations

Conserved Structural Features in the Interaction Between Retroviral Surface and Transmembrane Glycoproteins?

1992 • 91 citations

The organization of the envelope projections on the surface of HIV

1988 • 89 citations

Electron Microscopy of Human Immunodeficiency Virus

1988 • 88 citations

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1992 • 87 citations

Adaptation of Two Primary Human Immunodeficiency Virus Type 1 Isolates to Growth in Transformed T Cell Lines Correlates with Alterations in the Responses of Their Envelope Glycoproteins to Soluble CD4

1993 • 80 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

1992 • 79 citations

Production and of monoclonal antibodies to simian immunodeficiency virus envelope glycoproteins

1991 • 76 citations

Morphometric Analysis of Recombinant Soluble CD4-Mediated Release of the Envelope Glycoprotein gp120 from HIV-1

1990 • 72 citations

Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion.

1991 • 63 citations

Thermodynamic and Kinetic Analysis of sCD4 Binding to HIV-1 Virions and of gp120 Dissociation

1992 • 57 citations

Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein

1992 • 50 citations

Soluble CD4 enhances simian immunodeficiency virus SIVagm infection

1990 • 48 citations

Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain

1990 • 48 citations

Transmembrane envelope glycoproteins of human immunodeficiency virus type 2 and simian immunodeficiency virus SIV-mac exist as homodimers

1990 • 45 citations

Synthesis, oligomerization, and biological activity of the human immunodeficiency virus type 2 envelope glycoprotein expressed by a recombinant vaccinia virus

1990 • 43 citations

Cytopathic variants of an attenuated isolate of human immunodeficiency virus type 2 exhibit increased affinity for CD4

1991 • 37 citations

Hypothetical Assignment of Intrachain Disulfide Bonds for HIV-2 and SIV Envelope Glycoproteins

1991 • 36 citations

Human immunodeficiency virus type 2 envelope glycoprotein: Differential CD4 interactions of soluble gpl20 versus the assembled envelope complex

1992 • 35 citations

Correlation between kinetics of soluble CD4 interactions with HIV-1-Env-expressing cells and inhibition of syncytia formation

1992 • 34 citations

Differences in the interaction of HIV-1 and HIV-2 with CD4.

1990 • 34 citations

CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells

1990 • 31 citations

CD4 activation of HIV fusion

1992 • 30 citations

Study of the Interaction of HIV-1 and HIV-2 Envelope Glycoproteins with the CD4 Receptor and Role of N-Glycans

1992 • 28 citations

Strong Association of Simian Immunodeficiency Virus (SIVagm) Envelope Glycoprotein Heterodimers: Possible Role in Receptor-Mediated Activation

1992 • 23 citations

Oligomeric nature of transmembrane glycoproteins of HIV-2

1991 • 21 citations

Ultrastructure of Human Immunodeficiency Virus Type 2

1988 • 16 citations