Adaptation of Two Primary Human Immunodeficiency Virus Type 1 Isolates to Growth in Transformed T Cell Lines Correlates with Alterations in the Responses of Their Envelope Glycoproteins to Soluble CD4

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.

1990 • 975 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1

1991 • 871 citations

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule

1992 • 769 citations

Biologic Features of HIV-1 That Correlate with Virulence in the Host

1988 • 679 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain

1990 • 589 citations

REPLICATIVE CAPACITY OF HUMAN IMMUNODEFICIENCY VIRUS FROM PATIENTS WITH VARYING SEVERITY OF HIV INFECTION

1986 • 536 citations

Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 gene

1991 • 525 citations

Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution

1992 • 501 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

A General Model for the Transmembrane Proteins of HIV and Other Retroviruses

1989 • 375 citations

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

1991 • 326 citations

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo

1992 • 292 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.

1991 • 272 citations

Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity

1992 • 259 citations

Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation

1990 • 253 citations

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

1990 • 214 citations

Antibodies to discontinuous or conformationally sensitive epitopes on the gp120 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humans

1993 • 208 citations

Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins

1992 • 182 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Differential ability of human immunodeficiency virus isolates to productively infect human cells.

1987 • 171 citations

The role of the V3 loop of gp 120 in HIV infection

1991 • 165 citations

Neutralization of HIV‐1: a paradox of humoral proportions

1991 • 165 citations

The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.

1992 • 159 citations

Host range mutant of human immunodeficiency virus type 1: modification of cell tropism by a single point mutation at the neutralization epitope in the env gene

1991 • 154 citations

Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120

1991 • 142 citations

Replicative capacity, cytopathic effect and cell tropism of HIV

1989 • 137 citations

Enhancement of SIV Infection with Soluble Receptor Molecules

1990 • 136 citations

A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

1992 • 132 citations

AIDS pathogenesis: a dynamic interaction between HIV and the immune system

1990 • 129 citations

Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion.

1992 • 128 citations

Human immunodeficiency virus type 1 cellular host range, replication, and cytopathicity are linked to the envelope region of the viral genome

1990 • 124 citations

Identification of Envelope V3 Loop as the Major Determinant of CD4 Neutralization Sensitivity of HIV-1

1992 • 117 citations

The viral envelope gene is involved in macrophage tropism of a human immunodeficiency virus type 1 strain isolated from brain tissue

1990 • 113 citations

Phenotype-associated env gene variation among eight related human immunodeficiency virus type 1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain

1992 • 106 citations

Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type 1 clones derived from a single individual

1991 • 104 citations

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1991 • 101 citations

Functional interaction of constant and variable domains of human immunodeficiency virus type 1 gp120

1989 • 97 citations

Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptor.

1991 • 94 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity.

1991 • 91 citations

Conserved Structural Features in the Interaction Between Retroviral Surface and Transmembrane Glycoproteins?

1992 • 91 citations

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1992 • 87 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

1992 • 79 citations

The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitope

1990 • 75 citations

Quantifying the infectivity of human immunodeficiency virus.

1989 • 63 citations

Human immunodeficiency virus type 1 NL4-3 replication in four T-cell lines: rate and efficiency of entry, a major determinant of permissiveness

1991 • 63 citations

Blocking of human immunodeficiency virus infection depends on cell density and viral stock age

1991 • 57 citations

Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4

1992 • 57 citations

Thermodynamic and Kinetic Analysis of sCD4 Binding to HIV-1 Virions and of gp120 Dissociation

1992 • 57 citations

Two mutations in the envelope glycoprotein E2 of semliki forest virus affecting the maturation and entry patterns of the virus alter pathogenicity for mice

1991 • 55 citations

Relative inefficiency of soluble recombinant CD4 for inhibition of infection by monocyte-tropic HIV in monocytes and T cells.

1990 • 50 citations

Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein

1992 • 50 citations

Kinetics of HIV-1 interactions with sCD4 and CD4+ cells: Implications for inhibition of virus infection and initial steps of virus entry into cells

1992 • 48 citations

Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1

1992 • 48 citations

Altered host range of HIV-1 after passage through various human cell types

1991 • 47 citations

Cytopathic variants of an attenuated isolate of human immunodeficiency virus type 2 exhibit increased affinity for CD4

1991 • 37 citations

Differences in the interaction of HIV-1 and HIV-2 with CD4.

1990 • 34 citations

Mutations within the env gene of Mason-Pfizer monkey virus: effects on protein transport and SU-TM association

1992 • 33 citations

Replication of patient isolates of human immunodeficiency virus type 1 in T cells: a spectrum of rates and efficiencies of entry.

1992 • 30 citations

Human immunodeficiency virus type 1 entry into T cells: more-rapid escape from an anti-V3 loop than from an antireceptor antibody

1992 • 29 citations

Biological and molecular features of HIV-1 related to tissue tropism

1990 • 27 citations

Response

1991 • 16 citations

Differences in virion stability among Sindbis virus pathogenesis mutants

1988 • 13 citations