Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

A General Model for the Transmembrane Proteins of HIV and Other Retroviruses

1989 • 375 citations

Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1

1989 • 294 citations

Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4

1988 • 231 citations

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

1991 • 228 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 186 citations

HIV requires multiple gp120 molecules for CD4-mediated infection

1990 • 179 citations

Shedding and Interspecies Type Sero-reactivity of the Envelope Glycopolypeptide gp120 of the Human Immunodeficiency Virus

1986 • 177 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Studies with crosslinking reagents on the oligomeric structure of the env glycoprotein of HIV

1989 • 160 citations

Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay

1990 • 153 citations

The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule

1988 • 144 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

Neutralizing monoclonal antibodies to the AIDS virus

1988 • 124 citations

Characterization of recombinant gp120 and gp160 from HIV-1

1990 • 117 citations

Morphometric Analysis of Recombinant Soluble CD4-Mediated Release of the Envelope Glycoprotein gp120 from HIV-1

1990 • 72 citations

An enzyme-linked immunosorbent assay for antibodies to the envelope glycoproteins of divergent strains of HIV-1

1989 • 69 citations

The human immunodeficiency virus type 1 envelope glycoprotein precursor acquires aberrant intermolecular disulfide bonds that may prevent normal proteolytic processing

1990 • 61 citations

Characterization of in vitro inhibition of human immunodeficiency virus by purified recombinant CD4

1989 • 61 citations

Characterization of GP120 binding to CD4 and an assay that measures ability of sera to inhibit this binding.

1988 • 61 citations

Evaluation of Human and Simian Immunodeficiency Virus Plaque and Neutralization Assays

1989 • 50 citations

Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain

1990 • 48 citations

Differences in the interaction of HIV-1 and HIV-2 with CD4.

1990 • 34 citations

Enhancement of Soluble CD4-Mediated HIV Neutralization and gp120 Binding by CD4 Autoantibodies and Monoclonal Antibodies

1990 • 18 citations