Strong Association of Simian Immunodeficiency Virus (SIVagm) Envelope Glycoprotein Heterodimers: Possible Role in Receptor-Mediated Activation

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

1988 • 608 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III

1985 • 583 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins

1987 • 517 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

1988 • 442 citations

Characterization of gp41 as the Transmembrane Protein Coded by the HTLV-III/LAV Envelope Gene

1985 • 442 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein.

1990 • 360 citations

Identification of the residues in human CD4 critical for the binding of HIV

1989 • 357 citations

Complete Nucleotide Sequences of Functional Clones of the AIDS Virus

1987 • 348 citations

Membrane fusion activity of the influenza virus hemagglutinin. The low pH-induced conformational change.

1985 • 341 citations

Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1

1989 • 294 citations

Isolation of simian immunodeficiency virus from african green monkeys and seroepidemiologic survey of the virus in various non‐human primates

1988 • 284 citations

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

1991 • 228 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 186 citations

HIV requires multiple gp120 molecules for CD4-mediated infection

1990 • 179 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding

1988 • 175 citations

Studies with crosslinking reagents on the oligomeric structure of the env glycoprotein of HIV

1989 • 160 citations

Enhancement of SIV Infection with Soluble Receptor Molecules

1990 • 136 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4.

1991 • 130 citations

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

1988 • 120 citations

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1991 • 101 citations

Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptor.

1991 • 94 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity.

1991 • 91 citations

A plasma membrane component able to bind and alter virions of poliovirus type 1: Studies on cell-free alteration using a simplified assay

1977 • 75 citations

A conformational change in Sindbis virus glycoproteins E1 and E2 is detected at the plasma membrane as a consequence of early virus-cell interaction

1990 • 73 citations

Morphometric Analysis of Recombinant Soluble CD4-Mediated Release of the Envelope Glycoprotein gp120 from HIV-1

1990 • 72 citations

Use of a resin-bound synthetic peptide for identifying a neutralizing antigenic determinant associated with the human immunodeficiency virus envelope.

1987 • 59 citations

Isolation and Characterization of Simian Immunodeficiency Viruses from Two Subspecies of African Green Monkeys

1990 • 53 citations

Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain

1990 • 48 citations

Soluble CD4 enhances simian immunodeficiency virus SIVagm infection

1990 • 48 citations

Synthesis, oligomerization, and biological activity of the human immunodeficiency virus type 2 envelope glycoprotein expressed by a recombinant vaccinia virus

1990 • 43 citations

Cytopathic variants of an attenuated isolate of human immunodeficiency virus type 2 exhibit increased affinity for CD4

1991 • 37 citations

Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity

1991 • 34 citations

Overview

1990 • 2 citations