Thermodynamic and Kinetic Analysis of sCD4 Binding to HIV-1 Virions and of gp120 Dissociation

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

1990 • 407 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

1991 • 295 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus

1991 • 257 citations

The V3 Loops of the HIV-1 and HTV-2 Surface Glycoproteins Contain Proteolytic Cleavage Sites: A Possible Function in Viral Fusion?

1991 • 244 citations

Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4

1988 • 231 citations

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

1991 • 228 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1991 • 211 citations

Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 186 citations

Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells

1990 • 185 citations

HIV requires multiple gp120 molecules for CD4-mediated infection

1990 • 179 citations

Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4

1991 • 178 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Involvement of tryptase‐related cellular protease(s) in human immunodeficiency virus type 1 infection

1989 • 155 citations

Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay

1990 • 153 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

Characterization of recombinant gp120 and gp160 from HIV-1

1990 • 117 citations

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1991 • 101 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity.

1991 • 91 citations

Morphometric Analysis of Recombinant Soluble CD4-Mediated Release of the Envelope Glycoprotein gp120 from HIV-1

1990 • 72 citations

Characterization of in vitro inhibition of human immunodeficiency virus by purified recombinant CD4

1989 • 61 citations

Blocking of human immunodeficiency virus infection depends on cell density and viral stock age

1991 • 57 citations

Expression and purification of p24, the core protein of HIV, using a baculovirus-insect cell expression system

1990 • 24 citations

Response

1991 • 16 citations

Characterization of gp120 Binding to the CD4 Antigen and Detection of Specific Inhibitors

1990 • 6 citations