The Taiwanese hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.

1990 • 1,208 citations

Structure and organization of the hepatitis C virus genome isolated from human carriers

1991 • 970 citations

Isolation of a cDNA from the Virus Responsible for Enterically Transmitted Non-A, Non-B Hepatitis

1990 • 849 citations

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.

1990 • 640 citations

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

1991 • 636 citations

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

1991 • 611 citations

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

1991 • 609 citations

AMPLIFICATION OF RNA

1990 • 486 citations

The 5'-terminal sequence of the hepatitis C virus genome.

1990 • 481 citations

Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.

1991 • 426 citations

Expression of processed core protein of hepatitis C virus in mammalian cells

1991 • 147 citations

The hepatitis C virus and its relationship to the clinical spectrum of NANB hepatitis

1990 • 76 citations

Isolation of a complementary DNA fragment of hepatitis C virus in Taiwan revealed significant sequence variations compared with other isolates

1991 • 33 citations

Using Synthetic Oligonucleotides as Probes

1988 • 25 citations

ExoMeth sequencing of DNA: eliminating the need for subcloning and oligonucleotide primers.

1989 • 19 citations