Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Clinical Outcomes after Transfusion-Associated Hepatitis C

1995 • 1,228 citations

Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection

1996 • 1,016 citations

The Treatment of Chronic Viral Hepatitis

1997 • 974 citations

Expression and identification of hepatitis C virus polyprotein cleavage products

1993 • 890 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.

1995 • 638 citations

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

1991 • 636 citations

Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

1995 • 474 citations

The Folding Type of a Protein Is Relevant to the Amino Acid Composition

1986 • 448 citations

The PROSITE dictionary of sites and patterns in proteins, its current status

1993 • 353 citations

An algorithm for protein secondary structure prediction based on class prediction

1987 • 348 citations

The molecular virology of hepatitis C

1997 • 319 citations

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates.

1991 • 281 citations

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A

1995 • 281 citations

Production of Two Phosphoproteins from the NS5A Region of the Hepatitis C Viral Genome

1994 • 217 citations

Virus 'quasispecies': making a mountain out of a molehill?

1997 • 205 citations

Pretreatment Virus Load and Multiple Amino Acid Substitutions in the Interferon Sensitivity-Determining Region Predict the Outcome of Interferon Treatment in Patients With Chronic Genotype 1B Hepatitis C Virus Infection

1997 • 199 citations

Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

1997 • 194 citations

Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

1997 • 177 citations

Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-? therapy

1997 • 166 citations

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

1997 • 150 citations

Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa

1997 • 136 citations

Mutations of hepatitis C virus 1b NS5A 2209–2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

1997 • 124 citations

Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b

1997 • 119 citations

The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation

1997 • 115 citations

The Complete Coding Sequence of Hepatitis C Virus Genotype 5a, the Predominant Genotype in South Africa

1997 • 92 citations

The Amino Terminal Deletion Mutants of Hepatitis C Virus Nonstructural Protein NS5A Function as Transcriptional Activators in Yeast

1997 • 77 citations

ANTHEPROT 2.0: A three-dimensional module fully coupled with protein sequence analysis methods

1995 • 51 citations

Strong transient expression of the type I interferon–induced MxA protein in hepatitis A but not in acute hepatitis B and C

1994 • 42 citations

Purification and characterization of the NS3 serine protease domain of hepatitis C virus expressed in Saccharomyces cerevisiae.

1997 • 25 citations

Direct blotting electrophoresis for sequencing and genotyping hepatitis C virus

1997 • 7 citations