Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes

1989 • 1,004 citations

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

1992 • 613 citations

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

1993 • 454 citations

Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.

1991 • 426 citations

Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

1994 • 411 citations

Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

1993 • 310 citations

C-Terminal Domain of the Hepatitis C Virus NS3 Protein Contains an RNA Helicase Activity

1995 • 299 citations

The carboxy-terminal part of the NS 3 protein of the West Nile Flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase

1991 • 204 citations

A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3‘ to 5‘ direction.

1992 • 181 citations

Pestivirus NS3 (p80) protein possesses RNA helicase activity

1995 • 173 citations

Characterization of RNA Binding Activity and RNA Helicase Activity of the Hepatitis C Virus NS3 Protein

1996 • 146 citations

RNA-Stimulated NTPase Activity Associated with the p80 Protein of the Pestivirus Bovine Viral Diarrhea Virus

1993 • 117 citations

Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV

1995 • 103 citations

The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A

1995 • 100 citations

Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase

1995 • 81 citations

Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase

1995 • 72 citations

Group specific sequences and conserved secondary structures at the 3′ end of HCV genome and its implication for viral replication

1992 • 37 citations