Transcriptional Repression of p53 Promoter by Hepatitis C Virus Core Protein

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

The multistep nature of cancer

1993 • 1,872 citations

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

1990 • 1,108 citations

Expression and identification of hepatitis C virus polyprotein cleavage products

1993 • 890 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

1991 • 636 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Biosynthesis and biochemical properties of the hepatitis C virus core protein

1994 • 413 citations

Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

1996 • 412 citations

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells

1993 • 333 citations

Sequence analysis of the core gene of 14 hepatitis C virus genotypes.

1994 • 315 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

Suppression of Apoptotic Cell Death by Hepatitis C Virus Core Protein

1996 • 268 citations

Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein

1995 • 256 citations

Loss of p53 function through PAX-mediated transcriptional repression.

1995 • 236 citations

Interactions between SV40 large‐tumor antigen and the growth suppressor proteins pRB and p53

1993 • 180 citations

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 • 174 citations

A Cellular Homolog of Hepatitis Delta Antigen: Implications for Viral Replication and Evolution

1996 • 166 citations

Differential Subcellular Localization of Hepatitis C Virus Core Gene Products

1995 • 159 citations

Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation

1995 • 157 citations

Immune responses to plasmid DNA encoding the hepatitis C virus core protein

1995 • 157 citations

A reevaluation of the higher taxonomy of viruses based on RNA polymerases

1996 • 151 citations

Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted

1995 • 146 citations

Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.

1995 • 124 citations

Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.

1994 • 115 citations

Transcriptional Repression of p53 by Human T-cell Leukemia Virus Type I Tax Protein

1995 • 89 citations

Cultivation of hepatitis C virus in primary hepatocyte culture from patients with chronic hepatitis C results in release of high titre infectious virus

1996 • 89 citations

Loss of heterozygosity and analysis of mutation of p53 in hepatocellular carcinoma

1995 • 66 citations

Intracellular localization of full-length and truncated hepatitis C virus core protein expressed in mammalian cells

1994 • 53 citations

Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription

1996 • 48 citations

Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication

1996 • 38 citations

Cytogenetic approaches to human cancer genes ¹

1994 • 24 citations

Characterization of a live, attenuated human parainfluenza type 3 virus candidate vaccine strain

1995 • 12 citations