Regulation of Protein Synthesis by Insulin Through IRS-1

Current protocols in molecular biology

1988 • 7,584 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E

1999 • 635 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1998 • 510 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo

1999 • 449 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Model for the regulation of mRNA translation applied to haemoglobin synthesis

1974 • 416 citations

Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

1998 • 405 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1992 • 400 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

1998 • 369 citations

Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 Inactivation

1998 • 365 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.

1992 • 359 citations

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

1998 • 338 citations

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

1998 • 336 citations

eIF4E expression in tumors: its possible role in progression of malignancies

1999 • 327 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways

1998 • 302 citations

Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

1997 • 290 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

The IRS-signalling system during insulin and cytokine action

1997 • 280 citations

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

1995 • 276 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.

1995 • 269 citations

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

1995 • 268 citations

Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway.

1996 • 265 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

Translational Control

2013 • 230 citations

2 The Pathway and Mechanism of Eukaryotic Protein Synthesis

1996 • 225 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

1996 • 217 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

1994 • 212 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209

1995 • 210 citations

Insulin Activates Protein Kinases C-ζ and C-λ by an Autophosphorylation-dependent Mechanism and Stimulates Their Translocation to GLUT4 Vesicles and Other Membrane Fractions in Rat Adipocytes

1999 • 209 citations

p70 S6 kinase: an enigma with variations

1996 • 202 citations

Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.

1994 • 202 citations

Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis

1999 • 199 citations

Regulation of Protein Synthesis by Insulin

1994 • 198 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1996 • 193 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

Regulation of elongation factor‐2 by multisite phosphorylation

1993 • 181 citations

Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells

1996 • 170 citations

Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E

1991 • 168 citations

The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1

1996 • 167 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

1999 • 161 citations

Insulin Receptor Signaling Is Augmented by Antisense Inhibition of the Protein Tyrosine Phosphatase LAR

1995 • 160 citations

The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling

1998 • 159 citations

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G₁ phase of the cycle

1993 • 154 citations

Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways

1996 • 153 citations

Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells

1995 • 149 citations

Insulin and Exercise Decrease Glycogen Synthase Kinase-3 Activity by Different Mechanisms in Rat Skeletal Muscle

1999 • 141 citations

SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides.

1994 • 134 citations

Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation.

1995 • 131 citations

Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin

1997 • 127 citations

Protein Tyrosine Phosphatase 2 (SHP-2) Moderates Signaling by gp130 but Is Not Required for the Induction of Acute-Phase Plasma Protein Genes in Hepatic Cells

1998 • 121 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

The Nonreceptor Protein Tyrosine Phosphatase Corkscrew Functions in Multiple Receptor Tyrosine Kinase Pathways inDrosophila

1996 • 114 citations

Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling.

1994 • 109 citations

Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat Adipocytes

1999 • 107 citations

Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region.

1985 • 104 citations

Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)

1999 • 102 citations

Eukaryotic mRNAs encoding abundant and scarce proteins are statistically dissimilar in many structural features

1998 • 101 citations

The guanine nucleotide-exchange factor, eIF-2B

1994 • 101 citations

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3‐kinase

1997 • 101 citations

5 Protein Kinases That Phosphorylate eIF2 and eIF2B, and Their Role in Eukaryotic Cell Translational Control

1996 • 100 citations

The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains.

1992 • 100 citations

Phosphorylation of eIF-4E on Serine 209 by Protein Kinase C Is Inhibited by the Translational Repressors, 4E-binding Proteins

1996 • 98 citations

T-cell Activation Leads to Rapid Stimulation of Translation Initiation Factor eIF2B and Inactivation of Glycogen Synthase Kinase-3

1996 • 95 citations

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin's Metabolic and Mitogenic Effects

1997 • 92 citations

YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites

1996 • 91 citations

Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells

1996 • 90 citations

The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis

1996 • 88 citations

Protein kinase Cζ and n in murine epidermis TPA induces down‐regulation of PKCn but not PKCζ

1992 • 88 citations

Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.

1991 • 83 citations

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.

1995 • 80 citations

Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.

1994 • 78 citations

Nutrients differentially regulate multiple translation factors and their control by insulin

1999 • 78 citations

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation

1994 • 76 citations

Insulin‐stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

1996 • 76 citations

Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-ζ

1997 • 75 citations

Cap-Binding Protein (Eukaryotic Initiation Factor 4E) and 4E-Inactivating Protein BP-1 Independently Regulate Cap-Dependent Translation

1996 • 72 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

Translational control of ornithine aminotransferase. Modulation by initiation factor eIF-4E.

1991 • 66 citations

The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells

1999 • 64 citations

Coordinate Regulation of STAT Signaling and c-fosExpression by the Tyrosine Phosphatase SHP-2

1998 • 62 citations

Peptide Substrates Suitable for Assaying Glycogen Synthase Kinase-3 in Crude Cell Extracts

1997 • 59 citations

Regulation of Glycogen Synthase in Rat Hepatocytes

1999 • 58 citations

Different Signaling Roles of SHPTP2 in Insulin-induced GLUT1 Expression and GLUT4 Translocation

1995 • 55 citations

Translational control: a general mechanism for gene regulation during T cell activation

1998 • 54 citations

On the Mechanism of Cytosolic Phospholipase A2 Activation in CHO Cells Carrying Somatostatin Receptor: Wortmannin-Sensitive Pathway to Activate Mitogen-Activated Protein Kinase

1994 • 52 citations

Phosphorylation of Elongation Factor 1 and Ribosomal Protein S6 by Multipotential S6 Kinase and Insulin Stimulation of Translational Elongation

1997 • 50 citations

The cell cycle: myths and realities.

1990 • 49 citations

Insulin and Phorbol Ester Stimulate Initiation Factor eIF–4E Phosphorylation by Distinct Pathways in Chinese Hamster Ovary Cells Overexpressing the Insulin Receptor

1996 • 43 citations

Translational regulation of the mammalian growth-related protein P23: involvement of eIF-4E.

1994 • 42 citations

Insulin Induces Dephosphorylation of Eukaryotic Initiation Factor 2α and Restores Protein Synthesis in Vulnerable Hippocampal Neurons after Transient Brain Ischemia

1999 • 42 citations

Interactions of Protein Kinase C with Insulin Signaling

1996 • 29 citations

Casein kinase II is implicated in the regulation of heme-controlled translational inhibitor of reticulocyte lysates.

1994 • 27 citations

The accumulation of prominent tadpole mRNAs occurs at the beginning of neurulation in Xenopus laevis embryos

1984 • 26 citations

The activation of eukaryotic initiation factor (eIF)2B by growth factors in PC12 cells requires MEK/ERK signalling

2000 • 25 citations

Evidence for a Role of Phosphatidylinositol 3-Kinase in IL-4-Induced Germline Cϵ Transcription

1996 • 25 citations

Involvement of the rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats

1999 • 24 citations

Mechanism of differential regulation of IL-2 in murine Th1 and Th2 T cell subsets. 1. Induction of IL-2 transcription in Th2 cells by up-regulation of transcription factors with the protein synthesis initiation factor 4E.

1994 • 23 citations

Preparation of Cytoplasmic <scp>RNA</scp> from Tissue Culture Cells

2002 • 23 citations

Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts

1993 • 19 citations

The Phosphorylation of Protein S6 Modulates the Interaction of the 40 S Ribosomal Subunit with the 5′-Untranslated Region of aDictyostelium Pre-spore-specific mRNA and Controls Its Stability

1998 • 12 citations

Regulation of initiation factor elF-2B by GSK-3 regulated phosphorylation

1997 • 9 citations