Insulin and Phorbol Ester Stimulate Initiation Factor eIF–4E Phosphorylation by Distinct Pathways in Chinese Hamster Ovary Cells Overexpressing the Insulin Receptor

Antibodies, a laboratory manual

1989 • 12,929 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

The insulin signaling system.

1994 • 1,733 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209

1995 • 210 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Mechanism and regulation of eukaryotic protein synthesis.

1992 • 199 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1993 • 162 citations

Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells

1995 • 149 citations

Regulation of translation and cell growth by eIF-4E

1994 • 121 citations

Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F

1989 • 121 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

Comparative analysis of phosphorylation of translational initiation and elongation factors by seven protein kinases

1989 • 110 citations

Molecular mechanisms in the control of translation by hormones and growth factors

1994 • 101 citations

Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines.

1991 • 95 citations

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.

1992 • 86 citations

Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E.

1992 • 81 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

Ras-independent and Wortmannin-sensitive Activation of Glycogen Synthase by Insulin in Chinese Hamster Ovary Cells

1995 • 69 citations

Purification, phosphorylation and control of the guanine‐nucleotide‐exchange factor from rabbit reticulocyte lysates

1992 • 69 citations

Epidermal growth factor or okadaic acid stimulates phosphorylation of eukaryotic initiation factor 4F.

1991 • 61 citations

A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways

1995 • 55 citations

Increased rate of phosphorylation-dephosphorylation of the translational initiation factor eIF-4E correlates with the induction of protein and glycoprotein biosynthesis in activated B lymphocytes.

1990 • 55 citations

Evaluation of protein phosphorylation state by a combination of vertical slab gel isoelectric focusing and immunoblotting

1989 • 54 citations

Circular dichroism and fluorescence studies on protein synthesis initiation factor eIF-4E and two mutant forms from the yeast Saccharomyces cerevisiae.

1988 • 50 citations

Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations

1992 • 49 citations

α2 Adrenergic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells Activate Differentially Mitogen-activated Protein Kinase by a p21 Independent Pathway

1995 • 48 citations

Regulation of translation initiation and modulation of cellular physiology

1993 • 46 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E by Insulin-stimulated Protamine Kinase

1995 • 45 citations

Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.

1992 • 44 citations

Eukaryotic protein synthesis: An in vitro analysis

1994 • 43 citations

The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells.

1989 • 36 citations

The two forms of the β-subunit of initiation factor-2 from reticulocyte lysates arise from proteolytic degradation

1989 • 35 citations

Platelet‐derived growth factor stimulates phosphorylation of the 25 kDa mRNA cap binding protein (eIF‐4E) in human lung fibroblasts

1991 • 34 citations

High-resolution one-dimensional polyacrylamide gel isoelectric focusing of various forms of elongation factor-2

1992 • 24 citations

Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts

1993 • 19 citations

Modulation of the mitogenic activity of eukaryotic translation initiation factor-4E by protein kinase C.

1991 • 15 citations

EGF-Induced Activation of 70-kDa S6 Kinase in CHO Cells Expressing Human EGF Receptors

1995 • 10 citations