Insulin‐stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209

1995 • 210 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells

1995 • 149 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

Regulation of translation and cell growth by eIF-4E

1994 • 121 citations

Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II

1991 • 117 citations

Molecular mechanisms in the control of translation by hormones and growth factors

1994 • 101 citations

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.

1992 • 86 citations

Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E.

1992 • 81 citations

Participation of initiation factors in the recruitment of mRNA to ribosomes

1994 • 75 citations

Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations

1992 • 49 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E by Insulin-stimulated Protamine Kinase

1995 • 45 citations

Insulin and Phorbol Ester Stimulate Initiation Factor eIF–4E Phosphorylation by Distinct Pathways in Chinese Hamster Ovary Cells Overexpressing the Insulin Receptor

1996 • 43 citations

Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the α and γ subunits of the initiation factor complex eIF-4F

1995 • 37 citations

The two forms of the β-subunit of initiation factor-2 from reticulocyte lysates arise from proteolytic degradation

1989 • 35 citations

The effect of insulin and adrenaline on the phosphorylation of a 22000-molecular weight protein within isolated fat cells; possible identification as the inhibitor-1 of the ‘general phosphatase’

1980 • 35 citations

Comparison of the effects of insulin and adrenergic agonists on the phosphorylation of an acid-soluble 22 kDa protein in rat epididymal fat-pads and isolated fat-cells

1992 • 21 citations

Further characterization of the acid-soluble phosphoprotein (SDS/PAGE apparent molecular mass of 22 kDa) in rat fat-cells by peptide sequencing and immuno-analysis: effects of insulin and isoprenaline

1995 • 20 citations