The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes

1997 • 685 citations

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

1992 • 613 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

1995 • 541 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

1995 • 374 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

1998 • 369 citations

Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes

1996 • 341 citations

Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F

1998 • 338 citations

Life and death in the cytoplasm: messages from the 3′ end

1997 • 335 citations

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

1997 • 314 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

A Novel Functional Human Eukaryotic Translation Initiation Factor 4G

1998 • 297 citations

4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family

1998 • 292 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity

1997 • 261 citations

Translational Control

2001 • 248 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

1997 • 235 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

1995 • 225 citations

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

1996 • 217 citations

The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.

1996 • 207 citations

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1997 • 199 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Identification of Phosphorylation Sites in the Translational Regulator, PHAS-I, That Are Controlled by Insulin and Rapamycin in Rat Adipocytes

1997 • 193 citations

Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G

1997 • 175 citations

RNA Recognition Motif 2 of Yeast Pab1p Is Required for Its Functional Interaction with Eukaryotic Translation Initiation Factor 4G

1998 • 165 citations

eIF4G: translation's mystery factor begins to yield its secrets.

1997 • 163 citations

Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts

1998 • 151 citations

A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate

1996 • 139 citations

Involvement of Stress-activated Protein Kinase and p38/RK Mitogen-activated Protein Kinase Signaling Pathways in the Enhanced Phosphorylation of Initiation Factor 4E in NIH 3T3 Cells

1997 • 127 citations

Translational control of cellular and viral mRNAs

1996 • 118 citations

Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation.

1994 • 117 citations

Physiological stresses inhibit guanine‐nucleotide‐exchange factor in Ehrlich cells

1988 • 104 citations

Poly(A) binds to initiation factors and increases cap-dependent translation in vitro.

1994 • 101 citations

Control of the Translational Regulators PHAS-I and PHAS-II by Insulin and cAMP in 3T3-L1 Adipocytes

1996 • 99 citations

Phosphorylation of eIF-4E on Serine 209 by Protein Kinase C Is Inhibited by the Translational Repressors, 4E-binding Proteins

1996 • 98 citations

Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells

1996 • 90 citations

Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.

1993 • 90 citations

Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.

1991 • 83 citations

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.

1995 • 80 citations

Insulin‐stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

1996 • 76 citations

The role of eIF4 in cell proliferation.

1996 • 76 citations

Binding of Eukaryotic Translation Initiation Factor 4E (eIF4E) to eIF4G Represses Translation of Uncapped mRNA

1997 • 74 citations

Cap-Binding Protein (Eukaryotic Initiation Factor 4E) and 4E-Inactivating Protein BP-1 Independently Regulate Cap-Dependent Translation

1996 • 72 citations

Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1993 • 71 citations

Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation

1995 • 62 citations

Translational regulation of ribosomal protein synthesis in Xenopus cultured cells: mRNA relocation between polysomes and RNP during nutritional shifts

1992 • 57 citations

The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate

1997 • 53 citations

Signalling through either the p38 or ERK mitogen‐activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR‐CD3)‐stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells

1997 • 52 citations

Common themes in translational and transcriptional regulation

1997 • 50 citations

Insulin and Phorbol Ester Stimulate Initiation Factor eIF–4E Phosphorylation by Distinct Pathways in Chinese Hamster Ovary Cells Overexpressing the Insulin Receptor

1996 • 43 citations

Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the α and γ subunits of the initiation factor complex eIF-4F

1995 • 37 citations

Protein phosphorylation in cell growth regulation

1996 • 36 citations

The Wheat Poly (A)‐Binding Protein Functionally Complements Pab1 in Yeast

1997 • 29 citations

mRNA encoding the translation initiation factor eIF‐4E is expressed early in Xenopus embryogenesis

1995 • 26 citations

Serum and insulin regulate cap function in 3T3-L1 cells.

1994 • 23 citations

Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts

1993 • 19 citations