Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis

1982 • 362 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

1990 • 262 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes.

1987 • 171 citations

Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E

1991 • 168 citations

The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.

1991 • 112 citations

Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping

1988 • 104 citations

Effects of Insulin on Diacylglycerol–Protein Kinase C Signaling in Rat Diaphragm and Soleus Muscles and Relationship to Glucose Transport

1990 • 96 citations

The design and biological properties of potent and selective inhibitors of protein kinase C

1992 • 71 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

Insulin activation of protein kinase C: a reassessment

1991 • 65 citations

Cellular mechanisms involved in the action of insulin on protein synthesis

1988 • 62 citations

Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.

1992 • 44 citations

Rapid response of protein synthesis to insulin in 3T3 cells: Effects of protein kinase C depletion and differences from the response to serum repletion

1986 • 26 citations

Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: Evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism

1987 • 26 citations

Potential role of phospholipid‐signaling systems in insulin action and states of clinical insulin resistance

1989 • 23 citations

Insulin: Signal transmission and short-term effects on the cytoskeleton and protein synthesis

1992 • 20 citations

Phosphorylation of tyrosines 1158, 1162 and 1163 on a synthetic dodecapeptide by the insulin receptor protein-tyrosine kinase

1991 • 7 citations

Insulin action: Mechanisms involved in the effects of insulin on gene expression

1991 • 1 citations