Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

Removal of Fatty Acids from Serum Albumin by Charcoal Treatment

1967 • 2,098 citations

A simple method for the preparation of 32P-labelled adenosine triphosphate of high specific activity

1964 • 1,880 citations

Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme

1969 • 898 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors

1975 • 519 citations

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1974 • 492 citations

Subcellular components: preparation and fractionation;

1972 • 421 citations

Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones

1971 • 388 citations

Glycolytic Control Mechanisms

1965 • 373 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Regulation of Hepatic Acetyl Coenzyme A Carboxylase by Phosphorylation and Dephosphorylation

1973 • 337 citations

Carnitine in Intermediary Metabolism

1962 • 321 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles

1964 • 295 citations

α-Keto acid dehydrogenase complexes

1972 • 282 citations

Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart

1970 • 270 citations

Interactions of Metabolism and the Physiological Role of Insulin

1966 • 256 citations

A fluorimetric method for the quantitative microanalysis of adenine and pyridine nucleotides

1962 • 241 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and <scp>l</scp>-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

1964 • 226 citations

Biological Oxidoreductions

1964 • 221 citations

THE ENZYMATIC ACETYLATION OF AMINES

1953 • 209 citations

Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion

1967 • 195 citations

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication)

1973 • 174 citations

Pyruvate Dehydrogenase, Substrate Specificity and Product Inhibition

1969 • 161 citations

Regulation of Glutamate Metabolism and Interactions with the Citric Acid Cycle in Rat Heart Mitochondria

1973 • 158 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

α-Keto Acid Dehydrogenase Complexes

1973 • 149 citations

The coupling between energy-yielding and energy-utilizing reactions in mitochondria

1971 • 148 citations

Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo

1973 • 128 citations

Regulation of hepatic acetyl coenzyme a carboxylase by phosphorylation and dephosphorylation

1974 • 120 citations

Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies

1971 • 120 citations

Carnitine

1957 • 110 citations

Kinetic and Regulatory Properties of Heart Muscle Pyruvate Dehydrogenase

1969 • 107 citations

Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet

1976 • 105 citations

Regulation of Pyruvate Dehydrogenase in Rat Liver Mitochondria by Phosphorylation-Dephosphorylation

1974 • 104 citations

Mechanisms regulating adipose-tissue pyruvate dehydrogenase

1972 • 103 citations

Amino acid sequence of a (32P)phosphopeptide from pig liver pyruvate kinase phosphorylated by cyclic 3′,5′-AMP-stimulated protein kinase and γ-(32P)ATP

1974 • 102 citations

The Interaction of Energy and Electron Transfer Reactions in Mitochondria

1961 • 101 citations

Effects of Diabetes, Fatty Acids, and Ketone Bodies on Tricarboxylic Acid Cycle Metabolism in the Perfused Rat Heart

1966 • 91 citations

Comparison of acylcarnitines and pyruvate as substrates for rat-liver mitochondria

1966 • 89 citations

Activation of Pyruvate Dehydrogenase during Metabolism of Ammonium Ions in Hemoglobin‐Free Perfused Rat Liver

1975 • 85 citations

Determination of subpicomole levels of NADH and FMN using bacterial luciferase and the liquid scintillation spectrometer

1971 • 85 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 80 citations

Pyruvate metabolism in the perfused rat heart

1963 • 78 citations

Exchangeable and total calcium pools in mitochondria of rat epididymal fat-pads and isolated fat-cells. Role in the regulation of pyruvate dehydrogenase activity

1976 • 74 citations

Measurement of flow of carbon atoms from glucose and glycogen glucose to glyceride glycerol and glycerol in rat heart and epididymal adipose tissue. Effects of insulin, adrenaline and alloxan-diabetes

1967 • 72 citations

Regulation of Pyruvate-Dehydrogenase Interconversion in Rat-Liver Mitochondria as Related to the Phosphorylation State of Intramitochondrial Adenine Nucleotides

1974 • 69 citations

Control of pyruvate dehydrogenase activity in intact cardiac mitochondria. Regulation of the inactivation and activation of the dehydrogenase.

1975 • 59 citations

Recent advances in glycogen metabolism.

1974 • 52 citations

Calcium ions and the regulation of pyruvate dehydrogenase.

1974 • 52 citations

Studies on the Properties of (—)‐2‐α‐Hydroxyethyl‐Thiamine Pyrophosphate (“Active Acetaldehyde”)

1967 • 41 citations

An energy‐dependent transformation of a ferricytochrome of the mitochondrial respiratory chain

1972 • 28 citations

ATP controlled redox states of respiratory carriers under the influence of DPNH-hydrogen accepting substrates

1961 • 22 citations

[BIOSYNTHESIS OF ACETOIN IN PIG HEART MUSCLE].

1963 • 9 citations