METABOLISM OF PYRUVATE IN ANIMALS

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1974 • 492 citations

Regulation of Glucose Uptake by Muscle

1962 • 484 citations

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones

1971 • 388 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Regulation of mammalian pyruvate dehydrogenase

1975 • 299 citations

Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles

1964 • 295 citations

Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

1971 • 231 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

Active and Inactive Forms of Pyruvate Dehydrogenase in Rat Liver

1972 • 199 citations

Phosphorylation of purified rat liver pyruvate kinase by cyclic 3′,5′-AMP-stimulated protein kinase

1974 • 172 citations

Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3'-5'-monophosphate, and insulin in the perfused rat liver.

1976 • 168 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

Hormonal regulation of pyruvate dehydrogenase

1971 • 127 citations

Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies

1971 • 120 citations

Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

1977 • 117 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise

1976 • 104 citations

Mechanisms regulating adipose-tissue pyruvate dehydrogenase

1972 • 103 citations

Adipose-tissue pyruvate kinase. Properties and interconversion of two active forms

1968 • 96 citations

Interconversion of Pyruvate Dehydrogenase in the Isolated Perfused Rat Liver

1973 • 94 citations

The elementary reactions of the pig heart pyruvate dehydrogenase complex. A study of the inhibition by phosphorylation

1976 • 88 citations

Exchangeable and total calcium pools in mitochondria of rat epididymal fat-pads and isolated fat-cells. Role in the regulation of pyruvate dehydrogenase activity

1976 • 74 citations

Active and inactive forms of pyruvatedehydrogenase in skeletal muscle as related to the metabolic and functional state of the muscle cell

1975 • 71 citations

Activation of pyruvate dehydrogenase in adipose tissue by insulin. Evidence for an effect of insulin on pyruvate dehydrogenase phosphate phosphatase

1975 • 62 citations

Calcium ions and the regulation of pyruvate dehydrogenase.

1974 • 52 citations

Pyruvate Dehydrogenase Activation after an Increase in Cardiac Output

1976 • 25 citations