Incorporation of [32P]phosphate into the pyruvate dehydrogenase complex in rat heart mitochondria

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

1976 • 399 citations

Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones

1971 • 388 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios

1975 • 303 citations

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

1978 • 283 citations

Regulation of heart muscle pyruvate dehydrogenase kinase

1974 • 227 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

1975 • 141 citations

Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

1977 • 117 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Regulation of pig heart pyruvate dehydrogenase by phosphorylation. Studies on the subunit and phosphorylation stoicheiometries

1978 • 93 citations

Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex

1979 • 90 citations

Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase

1978 • 89 citations

Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan‐diabetes or starvation

1978 • 85 citations

Function of phosphorylation sites on pyruvate dehydrogenase

1979 • 73 citations

Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex

1979 • 72 citations

Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue

1976 • 63 citations

Inactivation of rat heart branched‐chain 2‐oxoacid dehydrogenase complex by adenosine triphosphate

1978 • 61 citations

Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat

1978 • 46 citations

Subcellular Components

1974 • 46 citations

Evidence for Multi-Site Phosphorylation of Pyruvate Dehydrogenase within Intact Mitochondria

1978 • 6 citations

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