Targeting of a chemically pure preprotein to mitochondria does not require the addition of a cytosolic signal recognition factor.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Mitochondrial protein import

1989 • 820 citations

Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria

1986 • 723 citations

Multiple Mechanisms of Protein Insertion into and Across Membranes

1985 • 720 citations

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

1989 • 676 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Protein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly

1990 • 494 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

THE ENZYMOLOGY OF PROTEIN TRANSLOCATION ACROSS THE Escherichia coli PLASMA MEMBRANE

1991 • 442 citations

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 414 citations

Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein

1988 • 388 citations

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

1988 • 380 citations

The role of the transit peptide in the routing of precursors toward different chloroplast compartments

1986 • 344 citations

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase

1986 • 340 citations

MOM19, an import receptor for mitochondrial precursor proteins

1989 • 334 citations

Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro.

1989 • 317 citations

A mitochondrial import receptor for the ADP/ATP carrier

1990 • 296 citations

An E. coli Ribonucleoprotein Containing 4.5 S RNA Resembles Mammalian Signal Recognition Particle

1990 • 285 citations

Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria

1991 • 278 citations

Successive translocation into and out of the mitochondrial matrix: Targeting of proteins to the intermembrane space by a bipartite signal peptide

1987 • 275 citations

The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.

1990 • 256 citations

Distinct steps in the import of ADP/ATP carrier into mitochondria.

1987 • 248 citations

How do polypeptides cross the mitochondrial membranes?

1990 • 246 citations

Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier.

1985 • 245 citations

The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix.

1984 • 236 citations

E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle

1990 • 212 citations

Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites.

1989 • 212 citations

SecA protein, a peripheral protein of the Escherichia coli plasma membrane, is essential for the functional binding and translocation of proOmpA.

1989 • 206 citations

Import of ADP/ATP carrier into mitochondria: two receptors act in parallel.

1990 • 201 citations

Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast.

1991 • 183 citations

Unfolding and refolding of a purified precursor protein during import into isolated mitochondria.

1988 • 182 citations

Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L(+)-lactate cytochrome c oxidoreductase (cytochrome b2).

1985 • 178 citations

Phosphodiester bond cleavage outside mitochondria is required for the completion of protein import into the mitochondrial matrix

1987 • 175 citations

Polypeptides traverse the mitochondrial envelope in an extended state

1990 • 172 citations

Targeting proteins into mitochondria

1986 • 171 citations

Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence.

1990 • 170 citations

Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site.

1988 • 159 citations

Transport and routing of proteins into chloroplasts

1989 • 155 citations

Purification of three related peripheral membrane proteins needed for vesicular transport.

1990 • 147 citations

Membrane and cytosolic components affecting transport of the precursor for ornithine carbamyltransferase into mitochondria.

1983 • 141 citations

Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites.

1987 • 134 citations

Mitochondrial protein import

1989 • 131 citations

A purified precursor polypeptide requires a cytosolic protein fraction for import into mitochondria.

1984 • 126 citations

The reaction specificities of the thylakoidal processing peptidase and Escherichia coli leader peptidase are identical.

1989 • 124 citations

Chapter 16 Analysis of Mitochondrial Protein Import Using Translocation Intermediates and Specific Antibodies

1991 • 115 citations

Protein transfer across microsomal membranes reassembled from separated membrane components

1978 • 114 citations

Purified presequence binding factor (PBF) forms an import-competent complex with a purified mitochondrial precursor protein.

1990 • 113 citations

Mitochondrial import receptors for precursor proteins

1991 • 112 citations

Import of proteins into mitochondria. Import and maturation of the mitochondrial intermembrane space enzymes cytochrome b2 and cytochrome c peroxidase in intact yeast cells.

1982 • 102 citations

The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle.

1991 • 101 citations

A cytosolic protein contains a cryptic mitochondrial targeting signal

1987 • 101 citations

Transport of ornithine carbamoyltransferase precursor into mitochondria. Stimulation by potassium ion, magnesium ion, and a reticulocyte cytosolic protein(s).

1983 • 86 citations

The cytosolic factor required for import of precursors of mitochondrial proteins into mitochondria.

1988 • 82 citations

Protein transport across the ER membrane

1990 • 75 citations

Functional dissection of the signal recognition particle

1988 • 70 citations

Import of chemically synthesized signal peptides into rat liver mitochondria.

1990 • 61 citations

Protein import into mitochondria and peroxisomes

1990 • 53 citations

An unusual mitochondrial import pathway for the precursor to yeast cytochrome c oxidase subunit Va.

1991 • 49 citations

How finicky is mitochondrial protein import?

1988 • 47 citations

More similarity between bakers' yeast L-(+)-lactate dehydrogenase and liver microsomal cytochrome b5

1975 • 43 citations

RNA Required for Import of Precursor Proteins into Mitochondria

1984 • 43 citations

Isolation and Properties of a Liver Mitochondrial Precursor Protein to Aspartate Aminotransferase Expressed in Escherichia coli

1989 • 43 citations

The precursor to ornithine carbamyl transferase is transported to mitochondria as a 5S complex containing an import factor

1985 • 39 citations

The role of protein structure in the mitochondrial import pathway. Analysis of the soluble F1-ATPase beta-subunit precursor.

1987 • 37 citations

Reconstitution of mitochondrial protein transport with purified ornithine carbamoyltransferase precursor expressed in Escherichia coli.

1988 • 35 citations

A bacterium catches up

1991 • 28 citations

Targeting of Nuclear-Encoded Proteins to the Mitochondrial Matrix: Implications for Human Genetic Defects

1986 • 27 citations

Cytosolic and mitochondrial surface factor-independent import of a synthetic peptide into mitochondria.

1991 • 25 citations

Import of a mutant mitochondrial precursor fails to respond to stimulation by a cytosolic factor

1989 • 22 citations

Protein export in prokaryotes and eukaryotes Theme with variations

1991 • 18 citations

Nucleotide sequence of a full-length cDNA coding for the mitochondrial precursor protein of the β-subunit of F₁-ATPase fromNeurospora crassa

1990 • 17 citations