Effects of DNA methylation on topoisomerase I and II cleavage activities.

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

The essentials of DNA methylation

1992 • 960 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

DNA topology and its biological effects

1991 • 612 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

1990 • 426 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.

1993 • 317 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

Catalytic function of DNA topoisomerase II

1991 • 246 citations

Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome.

1984 • 225 citations

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.

1991 • 199 citations

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics.

1992 • 181 citations

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

1989 • 172 citations

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1986 • 145 citations

Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin.

1987 • 137 citations

Rapid induction of c-fos transcription reveals quantitative linkage of RNA polymerase II and DNA topoisomerase I enzyme activities

1990 • 133 citations

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I

1989 • 126 citations

Drug-induced DNA hypermethylation and drug resistance in human tumors.

1989 • 119 citations

Developments of Cancer Chemotherapy

1980 • 113 citations

Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA

1982 • 112 citations

The Causes and Consequences of Chromosomal Aberrations

1992 • 110 citations

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin.

1986 • 96 citations

Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.

1993 • 95 citations

Nonrandom integration of retroviral DNA in vitro: effect of CpG methylation.

1992 • 94 citations

Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.

1993 • 87 citations

DNA topoisomerase II as a target of antineoplastic drug therapy

1985 • 83 citations

Topoisomerase II cleavage in chromatin

1986 • 79 citations

Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia

1991 • 77 citations

Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.

1992 • 73 citations

Interactions between eukaryotic DNA topoisomerase I and a specific binding sequence

1989 • 71 citations

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs

1991 • 70 citations

Sites of topoisomerase I action on X. laevis ribosomal chromatin: Transcriptionally active rDNA has an ∼200 bp repeating structure

1988 • 69 citations

Cytosine methylation can induce local distortions in the structure of duplex DNA

1992 • 63 citations

Topoisomerase I Interaction with SV4O DNA in the presence and absence of camptothecin

1988 • 57 citations

Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase.

1984 • 55 citations

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase in reconstituted Simian virus 40 chromatin

1990 • 54 citations

Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation

1991 • 54 citations

Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice

1989 • 52 citations

Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.

1992 • 49 citations

Specific interaction of camptothecin, a topoisomerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm

1993 • 45 citations

Site-specific interaction of vaccinia virus topoisomerase I with base and sugar moieties in duplex DNA.

1993 • 44 citations

In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene

1986 • 43 citations

DNA topoisomerase II cleaves at specific sites in the 5′ flanking region of c-fos proto-oncogenes in vitro.

1986 • 42 citations

Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation

1991 • 39 citations

Analysis of topoisomerase I and II cleavage sites on the Drosophila actin and Hsp70 heat shock genes

1992 • 37 citations

Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid.

1992 • 35 citations

DNA topoisomerases

1992 • 35 citations

Stimulation of the topoisomerase II induced DNA cleavage sites in the c-myc protooncogene by antitumor drugs is associated with gene expression

1989 • 33 citations

Somatic mutations in c-myc intron I cluster in discrete domains that define protein binding sequences.

1993 • 31 citations

Minimal DNA requirement for topoisomerase II-mediated cleavage in vitro.

1990 • 30 citations

Computational analysis of structural and energetic consequences of DNA methylation

1989 • 24 citations

Analysis of the Biased Distribution of Topoisomerase I Break Sites on Replicating Simian Virus 40 DNA

1993 • 18 citations

Characterization of the topoisomerase II-induced cleavage sites in the c-myc proto-oncogene

1986 • 16 citations

Identification of two novel mouse nuclear proteins that bind selectively to a methylated c-Myc recognizing sequence

1993 • 10 citations