Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

1991 • 287 citations

Induction of mammalian topoisomerase ii dependent dna cleavage by nonintercalative flavonoids, genistein and orobol

1990 • 219 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

1990 • 181 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.

1989 • 159 citations

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1986 • 145 citations

DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators

1987 • 134 citations

Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage

1985 • 127 citations

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide

1991 • 124 citations

Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus

1991 • 122 citations

Inhibition of type II topoisomerase by fostriecin

1988 • 116 citations

Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs.

1989 • 86 citations

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase in reconstituted Simian virus 40 chromatin

1990 • 54 citations

Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.

1992 • 49 citations

Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin.

1991 • 49 citations

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

1990 • 47 citations

Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.

1989 • 45 citations

Mammalian Topoisomerase II Activity Is Modulated by the DNA Minor Groove Binder Distamycin in Simian Virus 40 DNA

1989 • 45 citations

Synthesis and antitumor activity of podophyllotoxin aza-analogues

1989 • 45 citations

Effect of 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants.

1991 • 39 citations

E-ring desoxy analogs of etoposide

1989 • 27 citations

Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide

1990 • 26 citations