Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

DNA methylation and gene activity

1988 • 904 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia

1986 • 566 citations

Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression

1987 • 407 citations

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.

1991 • 311 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 245 citations

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

1986 • 215 citations

The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.

1988 • 197 citations

Fragile sites in human chromosomes as regions of late-replicating DNA

1987 • 158 citations

Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia [see comments]

1989 • 157 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 138 citations

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing

1990 • 135 citations

Detection of two alternative bcr/abl mRNA junctions and minimal residual disease in Philadelphia chromosome positive chronic myelogenous leukemia by polymerase chain reaction

1989 • 117 citations

Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies

1987 • 115 citations

CML patients in blast crisis have breakpoints localized to a specific region of the BCR

1987 • 100 citations

bcr-abl RNA in patients with chronic myelogenous leukemia

1987 • 99 citations

The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients [see comments]

1988 • 96 citations

Analysis of breakpoints within the bcr gene and their correlation with the clinical course of Philadelphia-positive chronic myelogenous leukemia

1988 • 92 citations

Abnormal methylation of the calcitonin gene in human colonic neoplasms.

1989 • 75 citations

Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia

1989 • 66 citations

Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation

1991 • 54 citations

Relationship of bcr breakpoint to chronic phase duration, survival, and blast crisis lineage in chronic myelogenous leukemia patients presenting in early chronic phase [see comments]

1990 • 51 citations

Breakpoint zone of bcr in chronic myelogenous leukemia does not correlate with disease phase or prognosis

1988 • 26 citations

Nuclear India: New reactor “not for bombs“

1985 • 13 citations

The use of in situ hybridization for detection of loss of the Y chromosome in males with pancytopenia.

1989 • 4 citations